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A:
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- 8. What are the advantages and disadvantages of mutation?6. The starting sequence of a gene changed from AUGTTCGACGTG, to AUGTTTTCGACGTG What type of mutation is this? To answer the question, please explain: I) what the mutation is? 2) what types of mutation do you know? 3) what are the possible outcomes of mutations? 143. An alteration of genetic information is shown below. A-G-T-A-C-C-G-A-T > A-G-T-G-A-T What type of mutation is this an example of?
- 6. Two possible paint mutations are the substitution of lysine for leucine or the substitution of serine for threonine. Which is likely to be more serious and why?11. Distinguish among silent, missense, and nonsense point mutations.1. Classify the type of mutation that have taken place: silent, missense and nonsense as a result of a single base substitution from UCG codon which codes for cysteine:a) AGC (ser): ________b) UGU (cys): ________c) GGC (gly): _______d) UGA (stop): _______e) UUC (phen): _______2. A single base addition and a single base deletion approximately 15 bases apart in the mRNA specifying the protein lysozyme from the bacterial virus T4 caused a change in the protein fromits wil-type composition….lys-ser-pro-ser-leu-asn-ala-ala-lys…..to the mutant form lys-val-his-his-leu-met-ala-alalys.a. Decipher the segment of mRNA for both the original protein and the double mutant.b. Which base was added? Which was deleted?3. Given is the 30 nucleotides in the human gene for hemoglobin (the oxygen-carrying protein in the red blood cells): 5’ TAC-CAC-GTG-GAC-TGA-GGA-CTC-CTC-TTC-AGA 3’a. What is the complementary strand?b. Deduce the mRNA in this coding region.c. What is the amino acid sequence based on this…
- 23. All of the following are beneficial effects of mutation, EXCEPT: * a. basis for skeletal disease therapy b. resistance to some diseases like HIV c. used to help treat or cure diseases like heart-related problems d. weakens the ability of the leukocytes to fight diseases and infection7. what is A single gene mutation that affects multiple properties of an organism?1. Transcribe and translate the mutated DNA sequences, CIRCLE the mutation, and classify each type of mutation as either Deletion, Insertion, or Substitution AND the effects of the mutation as either frameshift, missense, silent or nonsense. ۷۷۷۷ Original Sequence: mRNA sequence: Amino Acid Sequence: MET-TRP – ASN - ARG - CYS - STOP Mutated Sequence #1: mRNA Sequence: Amino Acid Sequence: Type of Mutation: Mutation Effect: Mutated Sequence #2: mRNA Sequence: Amino Acid Sequence: Type of Mutation: Mutation Effect: TACAC CTT G G C G A CG ACT AUGUG GAA C C G C UG CUGA TACAT CTTG G C G A C G ACT TAC GAC CTT G G C G A CG ACT First base of codon C A UUU UUC UUA UUG CUU CUC CUA CUG U AUU AUC >Phe Leu >Leu ACU ACC AUA ACA AUG Met ACG GUU GCU GUC GCC GUA GCA GUG GCG lle Second base of codon C A - Val UCU UCC UCA UCG CCU CCC CCA CCG >Ser >Pro Thr Ala UAU UAC UAA UAG CAU CAC CAA CAG AAU AAC AAA Lys AAG LYS GAU GAC Asp GAA >Glu GAG З туг >His G UGA UGG CGU CGC CGA CGG AGU Asn AGC- AGA AGG. GGU GGC…