3. Draw an IgG antibody. Label the following: a. The heavy and light chains b. The constant and variable domains c. The Fab and Fc domains d. The antigen binding site, e. The hinge region f. The amino and carboxyl termini g. Indicate approximately the location of critical glycosylation sites h. Indicate approximately where the CDR (hypervariable domains) are located
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- 1.A given B cell expresses only maternally or paternally derived heavy chains but never both. This observation is the result of A. antibodydiversity.B. isotypeswitching.C. allelicexclusion.D. affinitymaturation.E. randomVJgenerearrangement. 2.Which of the following antibody classes or isotypes facilitate the sequential binding of the C1, C4, C2, and C3 components of the complement system? A. IgAandIgD B. IgAandIgE C. IgDandIgM D. IgE and IgG E. IgMandIgG7. Select ALL the TRUE statements regarding antibody (specifically, immunoglobulin G) structure. а. The antigen-binding site is located in the Fab portion. b. The antigen-binding site is formed as a combination of variable domains from one heavy and one light chain. Only the Fab portion has variable domains. Snip C. d. Only the Fe portion has constant domains. e. The Fc portion contains bound carbohydrate. The heavy and light chains are linked by disulfide bonds. The two heavy chains are linked by disulfide bonds. f. g. h. Only the Fc portion has constant domains.V:OYIO A O ۳۱ آذار، ۲۰۲۱ -> B. Gluten. D. Gastric H+-K+ dependent ATPase. O E. Myelin basic protein. 1. Which of the following 5 points antibodies are of most use for the diagnosis of pernicious anemia: * D. Anti-IgG Fc C. Anti-nuclear. A. Anti-parietal cell. E. Anti-TSH receptor. B. Anti-thyroid peroxidase. 3. The best test for diagnosis 5 points of Type B Gastritis is: * المزید حذف تعديل المفضلة مشاركة
- 5. A diagram of an antibody IgG molecule is given below. Indicate the locations of the following items on the diagram by putting the letter next to those parts of the molecule. If a part occurs more than once, mark all copies of the part. If you want you can draw the structure, mark it, take a picture, and insert the photo. (a) (b) (d) (e) the heavy chains the light chains the antigen binding site(s) the hinge region the Fc regionDRAW IT Sketch a B cell antigen receptor. Label the Vand C regions of the light and heavy chains. Label theantigen-binding sites, disulfide bridges, and transmembrane region. Where are these features located relativeto the V and C regions?1. Match the type of hypersensitivity reaction with their cause. Type IV hypersensitivity reaction Type II hypersensitivity reaction Type III hypersensitivity reaction A. Effector T cells specific for the sensitizing Ag B. Immune complexes formed from IgG binding to soluble Ag C. Antibodies specific for altered components of human cells 2. Because the FceRI receptors on mast cells, basophils and eosinophils always have IgE bound, they have Ag-specific receptors that function similar to B and T cells. Of the following list of characteristics, which ones are unique to Mast cells, basophils, and eosinophils? Choose all that apply. A. Binding antigen triggers differentiation B. Many different IgEs can be found on the surface of one cell C. All of the IgEs on the surface of a…
- 16. The Type A Transferase enzyme, attaches N-acetylgalactosamine (GalNAc) to H-antigen epitopes; the Type B Transferase enzyme instead transfers galactose (Gal) to the H-antigen. Individuals with Type A blood thus have at minimum one copy of the active Type A Transferase, those with Type B have at minimum one copy of the active Type B Transferase, those with Type AB have one active copy of each, those with Type O have neither. Imagine an AB individual who acquires a mutation in their Type B Transferase gene that allows it to be active with either Gal or GalNAc. Make sure to include a brief justification for your answer to each question below. a. What blood type antigens would this individual express? b. If this individual had a child with a normal O partner, what possible blood type antigens could the child express? c. If this individual had a child with a homozygous dominant B partner (BB), what possible blood type antigens could the child express?Clear my choice Two antibodies, one is IgM and the other is IgG, both can bind to the same epitope. Which of the following is true about them? O a. They have almost same variable regioi and almost same constant region of the heavy chain. O b. They have almost same variable region but different constant region of the heavy chain. O c. They have different variable region and different constant region of the heavy chain. O d. They have different variable region but same constant region of the heavy chain. SLE is a. Cell mediated autoimmune disease.1. knowing that the Control is 6.22 x 10-20 moles.channel-2sec-1 and CFTR-CRISPR: 3.84x 10-20 moles.channel-2.sec how did they get the answer and explain how? Immunostaining using Quantum Dot fluorescence reveals that there are 5 CFTR channels/μm2 in the “CONTROL” and 81 CFTR channels/μm2 in the “CFTR-CRISPR”. Calculate the number of moles of Cl-transported per channel per second for both treatments. Note that there are 1x108 μm2 in each cm2
- 277. Which of the following best describes the reason that the B cell receptor cannot transduce signals to the inside the cell once it binds antigen? A. The receptor requires twice the amount of antigen to be activated because it contains two sites. antigen binding b. lga is rapidly dephosphorylated c. The cytoplasmic domain of the receptor consists of 3 amino acids. d. Immunoglobulins (Ig) are inflexible molecules5) In the event of an inflammation in the body, discuss the vaccine concept after stating what the proteins that cause this formation in the cell where the inflammation takes place and consequently cause the initiation of the fight against this foreign substance.22. Which of the following is NOT a characteristic of cell- mediated immunity? a. The cells originate in bone marrow b. Cells are processed in the thymus gland c. The activation of cell-mediated immunity can be suppressed d. They are antigen presenting cells e. All of the above are characteristics of cell-mediated immunity 23. All of the following could be possibly target sites for antimicrobials to limit the possibility of side effects except a. peptidoglycan b. parasitic glycolytic enzymes c. ergosterol C. d. RNA polymerase DNA gyrase e. 24. Lysogeny can result in all of the following EXCEPT a. persistent infections b. a bacteria expressing new genes c. transduction of genes C. d. the turning off of the host cell's transcriptional and translational machinery e. the definite destruction of an infected cell 25. Due to your patient's opsonization of a bacterial cell with C₂B, which of following did NOT occur a. interference of the patient's secondary viral infection b. bacterial cell…
