Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Which of the following amino acids have a role in the urea cycle (check all that apply)?
Aspartate
Arginine
Glutamate
Asparagine
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- Assume that all carbon atoms and nitrogen atoms in both alanine and aspartate are labelled with radioisotopes. Then, the radioisotope-labelled alanine and aspartate molecules areallowed to undergo metabolism in the liver. All carbon atoms and nitrogen atoms in both ureaand glutamine are found to be labelled with radioisotopes. Please write down the metabolic reactions that lead to the incorporation of radioisotope-labelled carbon and nitrogen atoms into urea and glutamine.arrow_forwardCan u help me to explain to me, please? I stuggled my homework and i need help to understand itarrow_forwardDiscuss the two roles of N-acetylglutamate in the urea cycle. Include relevant chemical structures and reactions. What is the regulatory function of N-acetylglutamate in the urea cycle? What is the other role of N-acetylglutamate in relationship to the urea cycle? Glutamate is the precursor for N-acetylglutamate. How is glutamate involved in the connection between the urea cycle and the CAC?arrow_forward
- Number 7arrow_forwardIn considering the rate of reaction for urea conversion, the enzyme is _____ , the substrate is ______and the products are _______and _______.arrow_forwardWrite an equation for the net reaction of the urea cycle.Show how the urea cycle is linked to the citric acid cycle.arrow_forward
- Number 8arrow_forwardimagine that you are running a sample on the HPLC that is comprised of aspartate and isoleucine. Which amino acid will elute (come off of) the column first? Why?arrow_forwardIdentify urea in the Urea cycle below and show/explain where the two Nitrogen atoms of urea originate from. 3 2 ATP + HCO3 + NH3 4 CPS-1 2 ADP, P₁ NH3 CH₂ CH₂ CH₂ HC-NH3 Coo 1 7 H₂N NH₂ H₂N O=UN ARG1 H₂O OPO3²- feeli. NH₂ CH₂ CH₂ OTC CH₂ P₁ HỘ—NH3* ·8-3-4-8 • ASL CH 5 ΝΗ CH₂ CH₂ CH₂ HỘNH3 COO NH₂ 3 3 ASS NH COO ΝΗ CH₂ CH₂ COO- CH₂ CH₂ HỘ NH3* COO 4 ATP PP₁ L-Asp AMParrow_forward
- Number 6arrow_forwardhyperammonemia in patients is compounded by the reality of the normal regulatory controls in the urea cycle. Explain how increased GDH oxidative deamination activity will inhibit the urea cycle.arrow_forwardIf aspartate is labeled with deuterium D (= H-2 = 12H), answer questions a-c to determine where the label will end up in oxaloacetate after the involvement of aspartate in the urea cycle.arrow_forward
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