2. ( Labeling molecules with isotopes has long been used to trace and characterize metabolic pathways. Upon oxidation in the mammalian liver of L- glutamate labeled as shown on the right, write the metabolic reactions that lead to the products as shown below using structure formulas. No need to include the enzymes. (a) succinate [ (1-14C)-succinate ] (b) (c) (d) citrulline [15NH2-CO-NH-(CH2)3-CH (NH3)-COO-] H 15 + 14! urea [ 15NH₂-CO-15NH₂] H-N H COO- aspartate [ (1-¹4C,2-15N)-L-aspartate and (4-14C,2-15N)-L-aspartate] C-H CH₂ L CH₂ ī COO- (2-14C,15N)-L-glutamate

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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2. (
Labeling molecules with isotopes has long been used to trace and
characterize metabolic pathways. Upon oxidation in the mammalian liver of L-
glutamate labeled as shown on the right, write the metabolic reactions that
lead to the products as shown below using structure formulas. No need to
include the enzymes.
(a)
succinate [ (1-14C)-succinate ]
(b)
(c)
(d)
citrulline [ 15NH2-CO-NH-(CH2)3-CH (NH3)-COO-]
H COO-
15,1 + 14 [
H-NC-H
urea [ 15NH₂-CO-15NH₂]
aspartate [ (1-14C,2-15N)-L-aspartate and (4-¹4C,2-¹5N)-L- aspartate ]
H CH₂
L
CH₂
COO-
(2-14C, 15N)-L-glutamate
Transcribed Image Text:2. ( Labeling molecules with isotopes has long been used to trace and characterize metabolic pathways. Upon oxidation in the mammalian liver of L- glutamate labeled as shown on the right, write the metabolic reactions that lead to the products as shown below using structure formulas. No need to include the enzymes. (a) succinate [ (1-14C)-succinate ] (b) (c) (d) citrulline [ 15NH2-CO-NH-(CH2)3-CH (NH3)-COO-] H COO- 15,1 + 14 [ H-NC-H urea [ 15NH₂-CO-15NH₂] aspartate [ (1-14C,2-15N)-L-aspartate and (4-¹4C,2-¹5N)-L- aspartate ] H CH₂ L CH₂ COO- (2-14C, 15N)-L-glutamate
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