1. The liver produces glucose to the rest of the body between meals by breaking down glycogen stores to form glucose-6-phosphate in the penultimate step. Glucose-6-phosphate is then converted to glucose by splitting off the phosphate (AG° = -3.3 kcal/mol). Why do you think that the liver removes the phosphate by hydrolysis, rather than reversing the glycolytic step where: glucose + ATP → G6P + ADP (AG°' = -4.0 kcal/mol)? By reversing this reaction the liver could generate both glucose and ATP.
1. The liver produces glucose to the rest of the body between meals by breaking down glycogen stores to form glucose-6-phosphate in the penultimate step. Glucose-6-phosphate is then converted to glucose by splitting off the phosphate (AG° = -3.3 kcal/mol). Why do you think that the liver removes the phosphate by hydrolysis, rather than reversing the glycolytic step where: glucose + ATP → G6P + ADP (AG°' = -4.0 kcal/mol)? By reversing this reaction the liver could generate both glucose and ATP.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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