1. The liver produces glucose to the rest of the body between meals by breaking down glycogen stores to form glucose-6-phosphate in the penultimate step. Glucose-6-phosphate is then converted to glucose by splitting off the phosphate (AG° = -3.3 kcal/mol). Why do you think that the liver removes the phosphate by hydrolysis, rather than reversing the glycolytic step where: glucose + ATP → G6P + ADP (AG°' = -4.0 kcal/mol)? By reversing this reaction the liver could generate both glucose and ATP.

1. The liver produces glucose to the rest of the body between meals by breaking down glycogen stores to form glucose-6-phosphate in the penultimate step. Glucose-6-phosphate is then converted to glucose by splitting off the phosphate (AG° = -3.3 kcal/mol). Why do you think that the liver removes the phosphate by hydrolysis, rather than reversing the glycolytic step where: glucose + ATP → G6P + ADP (AG°' = -4.0 kcal/mol)? By reversing this reaction the liver could generate both glucose and ATP.

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter6: Energy, Enzymes, And Biological Reactions

Section: Chapter Questions

Problem 4TYK: When glucose reacts with ATP to form glucose-6-phosphate: a. the synthesis of glucose-6-phosphate is...

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