structure so they can which below, II. While there are many different types of inhibitors, most have a very similar Of the molecules compete with the normal substrate (in this case dopamine). compound do you think has the most promise as an inhibitor?
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- Activity of thionamide is potentiated by all of the following, except:A. AnticoagulantsB. Beta blockersC. SulfasalazineD. ACE inhibitorsE. TheophyllineAll of the following augment activity of biguanides, except:A. MAO inhibitorsB. ACE inhibitorsC. Beta blockersD. Delayed calcium channel blockersE. ТetracyclinesSubstrates for MAO (monoamine oxidase) include monoaminergio neurotransmitters cuch as catecholamines like dopamine (see image below): Н. NH2 HO Which do you think ls an Inhibitor for MAO? *NH2 Option 1 Option 2 don Option 3 Baced on the anower above, what type of Inhibitor le it? Compatitive
- Which of the following peptides acts as the bodys endogenous analgesic? Choices A.Tyr-Glu-Glu-Phe-Leu B.Tyr-Gly—Gly-Phe-Met C.Glu-Cys-Gly D.Gly-Cys-Glu1a.Arrange these ligands in their order of potencies(high to low) 1b. Choose an appropriate concentration of Propranolol needed to block 50% of epinephrine or isoproterenol induced cAMP production via adrenergic receptors expressed in a cell culture model system. 1c. Which of the following has more affinity to bind to adrenergic receptors? And why?I. EpinephrineII. IsoproterenolIII. PropranololWhich of the following is a property of ephedrine? A. central nervous system stimulant B. analgesic C. anesthetic D. decongestant E. Both B and C are correct
- a. Why is there an adverse interaction between monoamine oxidase inhibitors (MAOIs) often given for psychological disorders and an epi pen? b. Epi pens deliver a fast, large dose of epinephrine and are used by people suffering severe allergic reactions. As an AR agonist, epinephrine plays no role in allergic reactions, so why is it used?Discuss how benzodiazepines affect the balance between the excitation and inhibition in the brain, taking into consideration their mechanism of action.51. Monoamine oxidase inhibitor is used to treat certain types of major depressive and phobic anxiety disorders. The concentration of which of the following compounds is most likely to be increased as a result of this treatment? A. Tryptophan B. Tyrosine C. Epinephrine Answer: C
- Many drugs and physiological mechanisms operate, directly or indirectly, by influencing [Ca2+]I, second messenger system, protein kinase and nuclear receptor. Discuss in detail on how the above interaction shows therapeutic effect by using any reference drug as an exampl6. Some AchE inhibitors can be used to treat Alzheimer's disease signs and symptoms. Pick one: True or false1. Which of the following drugs is not a cardioselective beta-blocker? *A. EsmololB. AtenololC. PropranololD. MetoprololE. Bisoprolol 2. It is the ability of a drug to initiate cellular effects.A. AgonistB. AntagonistC. EfficacyD. Intrinsic Activity 3. What type of antagonism is exemplified when the interaction of two (2) drugs whoseopposing actions in the body tend to cancel each other’s effect?A. Physiological antagonismB. Pharmacokinetic antagonismC. Chemical antagonismD. Non-competitive antagonismE. Pharmacological antagonism 4. Which enzyme breaks down the neurotransmitter of the parasympathetic nerve?A. Catechol-O-Methyl TransferaseB. AcetylcholinesteraseC. Monoamine OxidaseD. DecarboxylaseE. CYP isozymes 5. Which drug exhibits similar mechanism of action with Reserpine? *A. VesamicolB. PilocarpineC. Botulinum toxinD. EpinephrineE. Neostigmine 6. Which of the following drugs is not a muscarinic-receptor antagonist used tocounteract cholinergic transmission? *A. UrecholineB.…