Calculate incidence rate ratio comparing the three groups (1. Never used hormonal contraception, 2. Used hormonal contraception >6 month previously and 3. Any hormonal contraception). Use the Never used hormonal contraception group as a reference and use the age-adjusted incidence rates in Table 2. [DO NOT USE THE NUMBERS IN COLUMN 2 AND 3]
Calculate incidence rate ratio comparing the three groups (1. Never used hormonal contraception, 2. Used hormonal contraception >6 month previously and 3. Any hormonal contraception). Use the Never used hormonal contraception group as a reference and use the age-adjusted incidence rates in Table 2. [DO NOT USE THE NUMBERS IN COLUMN 2 AND 3]
Chapter28: Medications That Affect The Reproductive System
Section: Chapter Questions
Problem 22RQ
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Question
Calculate incidence rate ratio comparing the three groups (1. Never used hormonal contraception, 2. Used hormonal contraception >6 month previously and 3. Any hormonal contraception). Use the Never used hormonal contraception group as a reference and use the age-adjusted incidence rates in Table 2. [DO NOT USE THE NUMBERS IN COLUMN 2 AND 3]
Transcribed Image Text:Variable
Never used hormonal contraception
Used hormonal contraception >6 mo previously
Duration of current or recent use of hormonal contraception
Any hormonal contraception
<1 yr
1 to <5 yr
5 to 10 yr
>10 yr
Combined oral contraceptives
<1 yr
1 to <5 yr
5 to 10 yr
>10 yr
Time since most recent use of hormonal contraception
Any hormonal contraception
<1 yr
1 to <5 yr
5 to 10 yr
>10 yr
Combined oral contraceptives
<1 yr
1 to <5 yr
5 to 10 yr
>10 yr
No. of
Person-Yr
7,815,180
4,348,722
7,308,437
1,170,657
3,339,451
2,118,912
679,417
6,424,088
1,084,435
2,980,688
1,808,425
550,540
1,039,247
1,989,435
983,689
341,657
1,032,653
2,169,364
1,174,457
431,393
No. of Breast-
Cancer Events
5955
2883
2679
266
909
899
605
1935
194
603
652
486
455
1152
859
417
400
1166
1026
524
Age-Adjusted
Incidence Rate
no. of events/
100,000 person-yr
55
58
68
58
64
69
74
68
54
64
70 76
60
57
58
58
60
56
60
62
Adjusted Relative
Risk (95% CI)*
1.00 (Reference)
1.08 (1.03 to 1.13)
1.20 (1.14 to 1.26)
1.09 (0.96 to 1.23)
1.18 (1.10 to 1.27)
1.24 (1.15 to 1.34)
1.38 (1.26 to 1.51)
1.19 (1.13 to 1.26)
1.03 (0.89 to 1.19)
1.17 (1.07 to 1.27)
1.27 (1.16 to 1.38)
1.46 (1.32 to 1.61)
1.09 (0.99 to 1.29)
1.03 (0.96 to 1.10)
1.04 (0.97 to 1.12)
1.08 (0.97 to 1.20)
1.05 (0.95 to 1.17)
1.00 (0.93 to 1.06)
1.05 (0.98 to 1.13)
1.05 (0.96 to 1.16)
P Value
0.002
<0.001
0.73
0.55
Age-Adjusted Risk
Difference (95% CI)
no. of events/
100,000 person-yr
Reference
3 (1 to 6)
13 (10 to 16)
3 (-5 to 10)
9 (4 to 13)
14 (9 to 19)
19 (13 to 25)
13 (10 to 17)
-1 (-8 to 8)
9 (3 to 14)
15 (8 to 21)
21 (14 to 28)
5 (-1 to 11)
2 (-2 to 5)
3 (-1 to 7)
3 (-3 to 4)
5 (-2 to 12)
1 (-3 to 4)
5 (1 to 9)
7 (-1 to 16)
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