Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter C, Problem 8P
C.8 The inheritance of certain mutations of BRCA
Can you say with certainty that a woman inheriting a mutation of BRCA
In addition to inheriting a BRCA
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Explain the molecular mechanisms of cancers caused by a P53 gene mutation.
1.
a)Proteins that stimulate/promote progression through the cell cycle are encoded by (oncogenes or tumor suppressor genes). Boldface one.
b)Proteins that inhibit progression through the cell cycle are encoded by (oncogenes or tumor suppressor genes). Boldface one.
c)What is the difference between a proto-oncogene and an oncogene?
d)To cause cancer, proto-oncogenes require (1 or 2)allele(s) to be mutated and therefore are considered (dominant or recessive). The mutation results in a (loss or gain) of function. For each underlined pair, boldface one.
e)To cause cancer, tumor suppressor genes require (1 or 2)allele(s) to be mutated and therefore are considered (dominant or recessive). The mutation results in a (loss or gain) of function. For each underlined pair, boldface one.
d)To cause cancer, proto-oncogenes require (1 or 2)allele(s) to be mutated and therefore are considered (dominant or recessive). The mutation results in a (loss or gain) of function. For each underlined pair, boldface one.
e)To cause cancer, tumor suppressor genes require (1 or 2)allele(s) to be mutated and therefore are considered (dominant or recessive). The mutation results in a (loss or gain) of function. For each underlined pair, boldface one.
Chapter C Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. C - C.1 Identify the normal functions of the genes...Ch. C - Prob. 2PCh. C - C.3 For the retinal cancer retinoblastoma, the...Ch. C - C.4 Explain the following processes involving...Ch. C - C.5 In March an earthquake measuring...Ch. C - C.6 Radiation is frequently used as a part of the...Ch. C - C.7 Based on what you read in this chapter
Can a...Ch. C - C.8 The inheritance of certain mutations of BRCA...Ch. C - C.9 Go to the website http :// www . cancer . gov...Ch. C - C.10 What kind of information will be made...
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- How would you relate the cancer cellular pathophysiology with genomic instability?arrow_forwardWhich genetic cancer predisposition syndrome is caused by germ-line mutations in the p53 gene and is associated with the early onset of cancers and the development of multiple malignant lesions of diverse tissue origins?arrow_forwardPart 3C: Below is data from a pedigree trace of patients affected with mouse model of pancreatic cancer, and below are the observations regarding a new gene called 318 that is found on chromosome 5. Patient II-4 has two copies of loss of function variant alleles (or is homozygous for loss-of-function variant 318 allele). Patient I-2 has one copy of loss of function variant and one copy of unaffected allele (is heterozygous for loss-of-function variant 318 allele). Patient II-1 has two copies of unaffected allele (or is homozygous for unaffected 318 allele). |-1 1-2 Il-1 Il-2 Il-3 |l-4 II-5 II-1 III-2 III-3 Based upon data above, what is the mode of inheritance for mouse model for pancreatic cancer? Why?arrow_forward
- What significance do BRCA1 and BRCA2 have in regard to developing cancer, and what types of cancer are associated with these genes?arrow_forwardMutations in the BRCA genes have been shown to be related to a higher incidence of breast cancer in humans, and genetic tests are available that enable women to discover whether they carry versions of the gene associated with high risk. However, even early detection of breast cancer does not guarantee a cure. What considerations can you think of for and against advising women to take the tests? ·arrow_forwardIn 2010, the U.S. Department of Health and Human Services added alcoholic beverages to its list of known human carcinogens. Explain what types of cancer alcohol is related to; what steps should be taken to reduce the risk of developing alcohol-induced cancer; and what other factors, when combined with alcohol, increase the risk of developing cancer.arrow_forward
- Please discuss the difference between cancers caused by tumor viruses and cancers caused by oncogenes. Does the etiology of a cancer influence its manifestation?arrow_forwardDiscuss two reasons why the therapeutic use ofembryonic stem cells can present a problem.arrow_forwardWhat is meant by the "two-hit" model of cancer development? Describe this theory in detail and explain why this makes sense with the observation that cancer is typically seen in people who are >60 years of age.arrow_forward
- Tissues and differentiation a)Explain what is meant by termination and differentiation ).b) Explain the difference between an oncogenic and a tumour suppressor gene and describe how they are involved in the onset of cancerarrow_forwardhow are the hallmarks resisting cell death and enabling replicative immortality essential for cancer development. explain each in 3-5 sentences.arrow_forwardDescribe how mutations in genome maintenance factors promote tumorigenesis. Why would inactivation of a mis- match repair gene cause colon cancer?arrow_forward
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