BIOLOGY
12th Edition
ISBN: 9781260169614
Author: Raven
Publisher: RENT MCG
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Textbook Question
Chapter 9, Problem 4A
In comparing small G proteins like Ras and GPCR proteins, we can say that
a. both proteins have intrinsic GTPase activity that stops signaling.
b. both proteins are active bound to GTP.
c. Ras is active bound to GDP and GPCRs are active bound to GTP.
d. both a and b are true.
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Students have asked these similar questions
Consider this pathway: epinephrine --> receptor -->G-protein---> Adenyl Cyclase---> cAMP --> protein kinase --> transcription factors. Identify the effector.
A.
cAMP
B.
G protein-coupled receptor
C.
epinephrine
D.
adenyl cyclase
Which statement is not true about G proteins?
A.
They are integral membrane proteins.
B.
They are slowly inactivated by their own GTPase activity.
C.
They are multisubunit proteins consisting of α, β and γ subunits.
D.
They act as transducers for hormones
Ras proteins are activated when they
a. bind GTP.
b. release GTP.
c. bind GDP.
d. undergo acetylation.
Which of the following statements regarding signaling in normal cells and cancer cells is false?
a. In normal cells, RTK transphosphorylation is strictly dependent on ligand binding. Ligand binding promotes a
conformational change in the RTKS that is required for dimerization, and dimerization is required for
transphosphorylation.
b. Cancers cells that over-express RTK's can respond to tiny amounts of ligand, and in some instances signaling
can be ligand-independent.
c. Cancer cells that have established several autocrine signaling loops have a poor prognosis, because these
cells have enabled multiple independent mitogenic signal transduction pathways.
4
d. The extracellular ectodomains of all RTKS are highly conserved in primary sequence and structure.
e. RTKS have a hydrophilic extracellular ectodomain, and hydrophobic transmembrane domain, and a
hydrophilic cytoplasmic domain, which contains the catalytic portion of the protein.
Chapter 9 Solutions
BIOLOGY
Ch. 9.1 - Prob. 1LOCh. 9.1 - Prob. 2LOCh. 9.2 - Prob. 1LOCh. 9.3 - Prob. 1LOCh. 9.3 - Prob. 2LOCh. 9.4 - Prob. 1LOCh. 9.4 - Describe how information crosses the membrane in...Ch. 9.4 - Prob. 3LOCh. 9.4 - Prob. 4LOCh. 9.5 - Prob. 1LO
Ch. 9.5 - Prob. 2LOCh. 9 - Paracrine signaling is characterized by ligands...Ch. 9 - Signal transduction pathways a. are necessary for...Ch. 9 - The function of a ____is to add phosphates to...Ch. 9 - Which of the following receptor types is NOT a...Ch. 9 - How does the function of an intracellular receptor...Ch. 9 - Signaling through receptor tyrosine kinases often...Ch. 9 - Prob. 7UCh. 9 - Which of the following best describes the...Ch. 9 - Prob. 1ACh. 9 - The ion Ca2+ can act as a second messenger because...Ch. 9 - Different receptors can have the same effect on a...Ch. 9 - In comparing small G proteins like Ras and GPCR...Ch. 9 - Prob. 5ACh. 9 - The receptors for steroid hormones and peptide...Ch. 9 - Describe the common features found in all examples...Ch. 9 - The sheet of cells that form the gut epithelium...
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