Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 9, Problem 11PDQ
Consider the case where a mutation occurs that disrupts translation in a single human mitochondrion found in the oocyte participating in fertilization. What is the likely impact of this mutation on the offspring arising from this oocyte?
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Another way to study the role of proteins (e.g., transcription factors) that function in development is to microinject the mRNA that encodes a protein, or the purified protein itself, into an oocyte or embryo, and then determine how this affects the subsequent development of the embryo, larva, and adult. For example, if Bicoid protein is injected into the posterior region of an oocyte, the resulting embryo will develop into a larva that has anterior structures at both ends. Based on your understanding of the function of each developmental gene, what would be the predicted phenotype if the following proteins or mRNAs were injected into normal oocytes?
A. Nanos mRNA injected into the anterior end of an oocyte
B. Antp protein injected into the posterior end of an embryo
C. Toll mRNA injected into the dorsal side of an early embryo
Name three possible factors contributing to early asymmetries in a developing embryo (i.e. what are the kinds of things early on that lead to the development of the body axes - dn, a/p, l/r, etc)?
In the fruit fly drosophila melanogaster, the anterior-to-posterior body axis becomes segmented into distinct regions. explain the role of the genes bicoid and nanos in this process.
Discuss how the anterior portion of the anteroposterior axis is established in Drosophila. What aspects of oogenesis are critical in establishing this axis? What do you think would happen if the bicoid mRNA was not trapped at the anterior end but instead diffused freely throughout the oocyte?
Chapter 9 Solutions
Concepts of Genetics (11th Edition)
Ch. 9 - Chlamydomonas, a eukaryoric green alga, may be...Ch. 9 - In aerobically cultured yeast, a petite mutant is...Ch. 9 - DNA in human mitochondria encodes 22 different...Ch. 9 - Prob. 4NSTCh. 9 - In 2000, Rocco Baldelli was a first-round draft...Ch. 9 - In 2000, Rocco Baldelli was a first-round draft...Ch. 9 - Prob. 3CSCh. 9 - HOW DO WE KNOW? In this chapter, we focused on...Ch. 9 - Review the Chapter Concepts list on page 196. The...Ch. 9 - Streptomycin resistance in Chlamydomonas may...
Ch. 9 - A plant may have green, white, or green-and-white...Ch. 9 - In diploid yeast strains, sporulation and...Ch. 9 - Predict the results of a cross between ascospores...Ch. 9 - In Lymnaea, what results would you expect in a...Ch. 9 - In a cross of Lymnaea, the snail contributing the...Ch. 9 - In Drosophila subobscura, the presence of a...Ch. 9 - A male mouse from a true-breeding strain of...Ch. 9 - Consider the case where a mutation occurs that...Ch. 9 - What is the endosymbiotic theory, and why is this...Ch. 9 - In an earlier Problems and Discussion section (see...Ch. 9 - The specification of the anteriorposterior axis in...Ch. 9 - The maternal-effect mutation bicoid (bcd) is...Ch. 9 - (a) In humans the mitochondrial genome encodes a...Ch. 9 - Mutations in mitochondrial DNA appear to be...Ch. 9 - Researchers examined a family with an interesting...Ch. 9 - Payne, B. A. et al. (2013) present evidence that a...
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- In Drosophila subobscura, the presence of a recessive gene called grandchildless (gs) causes the offspring of homozygous females, but not those of homozygous males, to be sterile. Can you offer an explanation as to why females and not males are affected by the mutant gene?arrow_forwardOur understanding of maternal effect genes has been greatly aided by their identification in experimental organisms such as Drosophila melanogaster and Caenorhabditis elegans. In experimental organisms with a short generation time, geneticists have successfully searched for mutant alleles that prevent the normal process of embryonic development. In many cases, the offspring die at early embryonic or larval stages. These are called maternal effect lethal alleles. How would a researcher identify a mutation that produced a recessive maternal effect lethal allele?arrow_forwardDesign a hypothetical experiment to determine the role of microtubules in gamete nuclear migration during fertilization of a fruit fly Drosophila melanogaster.arrow_forward
- A typical somatic cell from a badger, which is a diploid, sexually reproducing animal, contains a total of 32 chromosomes. Gametogenesis in badgers is similar to humans. What is the genome size for the badger in terms of chromosome number? How many DNA molecules would be found in a secondary oocyte before dividing? How many chromosomes would be found in a cell at metaphase? How many DNA molecules should be in a tetraploid liver cell from the badger?arrow_forwardOne reason that worker bees forgo their own reproduction to help their sister (the queen) reproduce is that female bees are more closely related to their sisters than they are to their own offspring. This quirk of genetics results from the fact that bees have haplodiploid sex determination, in which females are diploid, with a mother and a father, but males are haploid, developing from unfertilized eggs. Because males are haploid, they produce sperm by mitosis. Explainwhy haplodiploid sex determination causes females to be more closely related to their sisters than to their offspring.arrow_forwardThe oncogenic protein BETA promotes entry into the S phase of the cell cycle. Phosphorylation of BETA at the amino acid Tyr98 causes BETA to be degraded by the proteasome, thus limiting its abundance. A mutation in the codon encoding Tyr98 changes this residue to Cys, which cannot be phosphorylated. What is the best description of this mutant allele?a) antimorphb) hypermorphc) hypomorphd) amorphe) neomorpharrow_forward
- a) Do the loss of function phenotypes differ between the genes between the genes in figure 1? What does this mean? b) What are the two cell types responsible for producing maternal gene products involved in terminal patterning in the Drosophila cocyte? In which of these two cell types is each of the three genes expressed? c) Based on the phenotypes you observed for the three genes, and on the differences in their expression patterns, which one of the genes do you think is the localised determinant of terminal patterning? d❘ From the gain-of-function experiments, do trunk and torso like work upstream or downstream of torso? Explain. (4 m e) How might you test which of the trunk and torso-like genes acts upstream of the other? f) The torso gene has been shown to have another important role in Drosophila development outside of terminal patterning. What do you think would be a good first experiment to do to begin to investigate possible other roles for the trunk or torso - like genes? C a…arrow_forwardWhy is parthenogenesis in bees considered to be a form of asexual reproduction? Select one: a. The male drone is made from a haploid egg. Fertilization is not part of the process to make a male drone. b. The formation of the original haploid cell was achieved using binary fission. c. Although genetic material is transferred from one cell to another using conjugation, the resulting cells will be identical to each other. d. The haploid male bees were made through the process of meiosis, so they are identical to the parent egg cell.arrow_forwardIn Drosophila sex determination (Check all that apply.) A) XY individuals transcribe the Sxl gene early but not late. B XX individuals carry the Sxl gene, XY individuals do not. XX individuals transcribe the Sxl gene, XY individuals do not. XX individuals express the Sxl protein, XY individuals do not. E) The Sxl transcript (Pre-MRNA) is spliced differently in XX compared to XY individuals.arrow_forward
- Nanos is a strict maternal-effect gene in Drosophila; that is not transcribed in the embryo. Mutations in nanos result in the loss of posterior structures in the embryo. Predict the phenotype (i.e. wild type or mutant) of the following embryos.arrow_forward“In an organism that reproduces asexually, there is no difference between a somatic cell mutation and a germ line mutation.” Is this statement true? Explain.arrow_forwardWhich of the following applies to the female sex determination in Drosophila melanogaster fruit flies? (Mark all that apply) When the X:A ratio is 1.0, the SXL gene is transcribed during the early embryonic stages. The SXL protein inhibits the expression of female differentiaion genes The SXL protein promotes the correct splicing of the Tra pre-mRNA so that functional Tra protein is made. The presence of the SXL protein promotes the correct splicing of the SXL pre-mRNA during later embryonic stages to ensure to continuous production of SXL protein. The Tra protein will stimulate the expression of male-specific genes.arrow_forward
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