Chapter 8, Problem 5Q

Summary Introduction

Introduction:

Effector T-cells utilize several markers from naïve T-cells. Most specifically, effector T-cells incorporate VLA-4 integrins instead of L-selectin that results in loss of homing for the lymph nodes and are subject to invade infection or wound site possessing macrophages. Effector T-cells also express higher levels in the inflamed tissue stimulated by the binding of VLA-4 with the VCAM-1 ligand on the cell surface of effector T-cells.