Concept explainers
To determine:
The differences in the effect of the mutation produced in a gene’s promoter and protein-encoding region.
Introduction:
The mutation is a change in the sequence of the cell’s DNA, which results in the formation of an altered protein. The substances that cause mutation are collectively known as mutagens. The promoter of the gene is responsible for initiating the transcription of the gene. The protein coding region of the gene is the portion that codes for a protein.
To determine:
The difference in the effect of mutation produced in intron and exon.
Introduction:
The mRNA that is made after transcription consists of both introns and exons. The introns are the non-coding regions, which do not code any protein. Exons are the protein coding regions which codes for the protein. The introns are removed after processing, and then only coding mRNA proceeds for translation.
To determine:
Whether the type of mutation affects the answer given by an individual.
Introduction:
The mutation is an alteration in the sequence of the cell’s DNA, which results in the formation of an altered protein. The substances that are involved in causing mutation are collectively called mutagens.
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BIOLOGY:THE ESSENTIALS (LL) W/CONNECT
- Amino acids are translated from mRNA codons and each codon is made up of three nucleotide bases. How might an extra single base INSERTION into the second codon of a coding sequence of a gene affect the amino acid sequence of the protein encoded by the gene? (Hint: You may want to write out a made-up example of an insertion like the one described above) The entire amino acid sequence would shift and be changed. O A single amino acid would change only. O The mutation may have no effect on the amino acid sequence. O A single extra amino acid would be present in the protein. O All of the above are possible outcomes.arrow_forwardYou may wish to consult the genetic code above to answer the following question. A mutation has changed a portion of a protein coding gene that encodes a messenger RNA sequence. The original messenger RNA sequence is 5'-AUGCCCAGAGCU-3' Which mutation is a frameshift mutation that changes all of the amino acids that follow the changed sequence? O 5-AUGCCCUGAGCU-3' 05-AUGCCCCAGAGCU-3" 05-AUGCCCACAGCU-3" 05 AUGCCCAGGGCC-3"arrow_forwardWhich of the following mutations would be most likely to have the most negative effect on the functioning of a protein produced by the gene? Group of answer choices a deletion of one nucleotide at the beginning of the coding sequence a substitution of one nucleotide at the beginning of the coding sequence an insertion of three nucleotides near the end of the coding sequence a substitution of one nucleotide near the end of the coding sequencearrow_forward
- Indicate which of the following items are associated with transcription or translation. This could be in prokaryotes or eukaryotes, or both. Group of answer choices: Translation OR Transcription Sigma binds to the promoter mRNA binds to the small ribosomal subunit Spliceosomes remove introns and splice together exons Nucleotides are added from the 5' to 3' end tRNA anticodon binds to the corresponding mRNA codon STOP codon results in terminationarrow_forwardWhat happens when one base pair of DNA is lost from the coding region of a gene because of mutation? First explain how this would affect the mRNA sequence, and second, explain how this would alter the amino acid of the protein that is encoded.arrow_forwardWhat are the classes of mutations that can be made in the genetic code? In your own words describe how each class of mutation changes the protein that gets madearrow_forward
- If the codon AAA is mutated to AAG, it still codes for the amino acid, lysine, and the protein remains functionally the same; which of the following would best describe the result of this mutation? 1) frameshift mutation. O 2) insertion mutation. O 3) silent mutation. 4) nonsense mutation. O 5) back mutation.arrow_forwardWhich statement is false: A) Each type of protein ( ex: hemoglobin vs trypsionngen) varies in the length and amino acid sequence of its peptide B) After the rpocess of transcription is complete, the mRNA that is produced will continue being tranlsated by ribosomes for the rest of the cells life. mRNA never breaks down C) A ribosome will bind to an mRNA and will translate the sequence by reading one codon at a time and adding one amino acid to the peptide chain. It will stop the translation once it encounters a stop codon D) The gene for a protein provides the information on the legth of the peptide, along w the amino acid sequence so the protein can be synthesized by a ribosome E) Once mRNA has left the nucleus, ribosomes will bind to it and will follow the instructions in its sequence to make the new protienarrow_forwardCystic Fibrosis is a genetically heritable disease caused by the loss of the chloride channel, CFTR. Studies of this gene have found that the Gene includes 250,000bp in the DNA. Scientists found that the mRNA had 6,500 nucleotides, and the final protein had 1480 amino acids. How much of the mRNA is untranslated? How much of the RNA that is produced does not leave the nucleus? One of the mutations that results in a disease phenotype can be easily identified because the mutation results in a much longer mRNA then normal. Where would you look for this mutation? What might this mutation have affected?arrow_forward
- Define both transcription and translation. In addition, describe the role(s) of each of the following in the processes of gene expression and protein synthesis: DNA, mRNA, tRNA, rRNA, ribosome(s), RNA polymerase, codon, anticodon, amino acid(s) and polypeptide(s). Be detailed in your answer.arrow_forwardA certain mRNA strand has the following nucleotide sequence: 5AUGACGUAUAACUUU3 What is the anticodon for each codon? What is the amino acid sequence of the polypeptide? (Use Figure 13-5 to help answer this question.) Figure 13-5 The genetic code The genetic code specifies all possible combinations of the three bases that compose codons in mRNA. Of the 64 possible codons, 61 specify amino acids (see Figure 3-17 for an explanation of abbreviations). The codon AUG specifies the amino acid methionine and also signals the ribosome to initiate translation (start). Three codonsUAA, UGA, and UAGdo not specify amino acids; they terminate polypeptide synthesis (stop).arrow_forwardIf the coding region of a gene (the exons) contains 2,100 base pairs of DNA, would a missense mutation cause a protein to be shorter, longer, or the same length as the normal 700 amino acid proteins? What would be the effect of a nonsense mutation? A sense mutation?arrow_forward
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