Biochemistry: Concepts and Connections (2nd Edition)
Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 7, Problem 14P

Suppose your biking partner claims that hyperventilating at the bottom of steep hill climbs is a good idea because it will “increase the O2 saturation of the blood” and thereby provide “more O2 for leg muscles during the climb. “Hyperventilation reduces the CO2 content of blood. Given this fact, is hyperventilation likely to increase O2 delivery to muscles (as your biking partner claims) or not?

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Why should the total oxygen delivery be much lower than indicated by a particular PaO2 value?
During strenuous exercise, the oxygen-hemoglobin dissociation curve shifts to the right. This rightward shift reflects an increase in the affinity of hemoglobin for oxygen and favors loading of O2 onto hemoglobin in the lungs
Explain why, in a healthy person at sea level, increasing the alveolar (and therefore the arterial) PO2 either by hyperventilating or by breathing 100% oxygen does not appreciably increase the total content of oxygen in the blood?
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