The condition that happens to the muscles (including breathing muscles), if a toxic dose of curare entered the bloodstream. Introduction: Curare is a plant extract alkaloid, a toxic material. This is a classic antagonist of nicotinic acetylcholine (Ach) receptors which competes with the binding site of acetylcholine. This is mostly effective as the neuromuscular blocking agent and used as an anesthesia.

Question

You're hiking, you step on a piece of wood and a protruding rusty nail goes right through your Puma Cydes and into your foot. You start thinking....when was my last tetanus booster shot??? We're not talking about tetanus as defined in our studies of muscle physiology, but pathological tetanus (also known as "lockjaw"). In this condition, bacteria called Clostridia tetani (found in dirt) enter the bloodstream and grow, producing tetanus neurotoxin. The result of this toxin coursing through your bloodstream is causes the prime mover and its antagonist muscle groups (doesn't just have to be muscles of the jaw) to contract at the same time. How does the neurotoxin do that? Knowing all this, and being experts on Human reflex Physiology, do you think your reflexes (like the knee-jerk) would still function if you were suffering from "lock-jaw?"

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Question

Chapter 6, Problem 3CT

Summary Introduction

To explain: The condition that happens to the muscles (including breathing muscles), if a toxic dose of curare entered the bloodstream.

Introduction: Curare is a plant extract alkaloid, a toxic material. This is a classic antagonist of nicotinic acetylcholine (Ach) receptors which competes with the binding site of acetylcholine. This is mostly effective as the neuromuscular blocking agent and used as an anesthesia.

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You're hiking, you step on a piece of wood and a protruding rusty nail goes right through your Puma Cydes and into your foot. You start thinking....when was my last tetanus booster shot??? We're not talking about tetanus as defined in our studies of muscle physiology, but pathological tetanus (also known as "lockjaw"). In this condition, bacteria called Clostridia tetani (found in dirt) enter the bloodstream and grow, producing tetanus neurotoxin. The result of this toxin coursing through your bloodstream is causes the prime mover and its antagonist muscle groups (doesn't just have to be muscles of the jaw) to contract at the same time. How does the neurotoxin do that? Knowing all this, and being experts on Human reflex Physiology, do you think your reflexes (like the knee-jerk) would still function if you were suffering from "lock-jaw?"

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