Human Heredity: Principles and Issues (MindTap Course List)
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 6, Problem 19QP

The majority of nondisjunction events leading to Down syndrome are maternal in origin. Based on the duration of meiosis in females, speculate on the possible reasons for females contributing aneuploid gametes more frequently than males do.

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Briefly describe nondisjunction in meiosis and identify several potential consequences. In other words, what are the possible outcomes?
Though an individual with abberations such as Robertsonian translocation may be phenotypically normal, they can generate gametes through meiosis that have atypical organizations of chromosomes, resulting in recurrent fetal abnormalities or miscarriages. Why, despite these Robertsonian translocations, are affected cells still able to generate typical gametes through meiosis?
A diploid (2n) trihybrid individual with the genotype EeFfGg can make eight genetically different gametes.  Loci E/e and F/f are on chromosome 1 and locus G/g is on chromosome 2. Explain how a gamete containing the alleles e, f and g may be produced by meiosis. Refer specifically to meiotic events occurring during Prophase I, Metaphase I, Anaphase I and Anaphase II. (NB: remember to refer to the organism above).

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Human Heredity: Principles and Issues (MindTap Course List)

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