Biochemistry
9th Edition
ISBN: 9781305961135
Author: Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher: Cengage Learning
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Textbook Question
Chapter 6, Problem 14RE
REFLECT AND APPLY The enzyme lactate dehydrogenase catalyzes the reaction
NADH absorbs light at 340 nm in the near-ultraviolet region of the
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Biochemical reactions often look more complex than they really are. In the pentose phosphate pathway, sedoheptulose
7-phosphate and glyceraldchyde 3-phosphate react to form erythrose 4-phosphate and fructose 6-phosphate in a reaction
catalyzed by transaldolase.
CH,OH
C=0
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H-C-OH
一進
ÇH,OH
но-с-н
H-C-OH
H-C-OH
CH,OPO;
H-C-OH
H-C-OH
H-C-OH
ČH,OPO
H-C-OH
transaldolase H-C-OH
ČH,OPO
CH,OPO;
Sedoheptulose Glyceraldehyde
7-phosphate
Erythrose
4-phosphate
Fructose
6-phosphate
3-phosphate
Draw the mechanisms for the two steps of this reaction using curved double-barbed arrows to show the movement of electrons.
Do not delete any of the existing bonds, charges., or lone pairs.
Draw the first step of the reaction. : B represents a deprotonated base in the enzyme's active site.
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Rings
Groups
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Erase
H.
Draw the first step of the rcaction. : B represents a deprotonated base in the enzyme's active site.
Select
Draw
Rings
Groups
More
Erase
CH,OH
CH,OH
HO-C-H
H-C-OH
H-C-OH
CH,OPO;…
Chapter 6 Solutions
Biochemistry
Ch. 6 - RECALL How does the catalytic effectiveness of...Ch. 6 - RECALL Are all enzymes proteins?Ch. 6 - MATHEMATICAL Catalase breaks down hydrogen...Ch. 6 - REFLECT AND APPLY Give two reasons why enzyme...Ch. 6 - RECALL For the reaction of glucose with oxygen to...Ch. 6 - REFLECT AND APPLY Would nature rely on the same...Ch. 6 - REFLECT AND APPLY Suggest a reason why heating a...Ch. 6 - REFLECT AND APPLY A model is proposed to explain...Ch. 6 - REFLECT AND APPLY Does the presence of a catalyst...Ch. 6 - REFLECT AND APPLY What effect does a catalyst have...
Ch. 6 - REFLECT AND APPLY An enzyme catalyzes the...Ch. 6 - REFLECT AND APPLY Can the presence of a catalyst...Ch. 6 - RECALL For the hypothetical reaction 3A+2B2C+3D...Ch. 6 - REFLECT AND APPLY The enzyme lactate dehydrogenase...Ch. 6 - REFLECT AND APPLY Would you use a pH meter to...Ch. 6 - REFLECT AND APPLY Suggest a reason for carrying...Ch. 6 - RECALL Distinguish between the lock-and-key and...Ch. 6 - RECALL Using an energy diagram, show why the...Ch. 6 - REFLECT AND APPLY Other things being equal, what...Ch. 6 - REFLECT AND APPLY Amino acids that are far apart...Ch. 6 - REFLECT AND APPLY If only a few of the amino acid...Ch. 6 - RECALL Show graphically how the reaction velocity...Ch. 6 - RECALL Define steady state, and comment on the...Ch. 6 - RECALL How is the turnover number of an enzyme...Ch. 6 - MATHEMATICAL For an enzyme that displays...Ch. 6 - MATHEMATICAL Determine the values of KM and Vmax...Ch. 6 - MATHEMATICAL The kinetic data in the following...Ch. 6 - MATHEMATICAL The enzyme -methylaspartase catalyzes...Ch. 6 - MATHEMATICAL The hydrolysis of a...Ch. 6 - MATHEMATICAL For the Vmax obtained in Question 26,...Ch. 6 - MATHEMATICAL You do an enzyme kinetic experiment...Ch. 6 - REFLECT AND APPLY The enzyme D-amino acid oxidase...Ch. 6 - REFLECT AND APPLY Why is it useful to plot rate...Ch. 6 - REFLECT AND APPLY Under what conditions can we...Ch. 6 - BIOCHEMICAL CONNECTIONS Why does acetazolamide...Ch. 6 - BIOCHEMICAL CONNECTIONS How did scientists...Ch. 6 - BIOCHEMICAL CONNECTIONS How do the KM values for...Ch. 6 - Prob. 38RECh. 6 - RECALL What are the three most common mechanisms...Ch. 6 - RECALL What is the biggest difference between a...Ch. 6 - RECALL How do scientists determine the KM of a...Ch. 6 - Prob. 42RECh. 6 - Prob. 43RECh. 6 - RECALL Do all enzymes display kinetics that obey...Ch. 6 - RECALL How can you recognize an enzyme that does...Ch. 6 - RECALL If we describe an enzyme like aspartate...Ch. 6 - RECALL How can competitive and pure noncompetitive...Ch. 6 - RECALL Why does a competitive inhibitor not change...Ch. 6 - RECALL Why does a pure noncompetitive inhibitor...Ch. 6 - RECALL Distinguish between the molecular...Ch. 6 - RECALL Can enzyme inhibition be reversed in all...Ch. 6 - RECALL Why is a Lineweaver-Burk plot useful in...Ch. 6 - RECALL Where do lines intersect on a...Ch. 6 - RECALL What is the difference between pure and...Ch. 6 - REFLECT AND APPLY Why can we say that having a...Ch. 6 - REFLECT AND APPLY When we compare the binding of I...Ch. 6 - RECALL Why does the apparent KM decrease in the...Ch. 6 - RECALL What is a suicide substrate? Why are they...Ch. 6 - RECALL If we made a Lineweaver-Burk plot of an...Ch. 6 - Prob. 60RECh. 6 - MATHEMATICAL For the following aspartase reaction...Ch. 6 - REFLECT AND APPLY Is it good (or bad) that enzymes...Ch. 6 - REFLECT AND APPLY Noncompetitive inhibition is a...Ch. 6 - BIOCHEMICAL CONNECTIONS You have been hired by a...Ch. 6 - REFLECT AND APPLY Would you expect an irreversible...Ch. 6 - REFLECT AND APPLY Would you expect the structure...Ch. 6 - Prob. 67RECh. 6 - Prob. 68RE
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- REFLECT AND APPLY Show how the reactions of the electron transport chain differ from those in Question 3 when FADH2 is the starting point for electron transport. Show how the reactions that liberate enough energy to drive the phosphorylation of ADP differ from the pathway when NADH is the starting point.arrow_forwardREFLECT AND APPLY The malate-aspartate shuttle yields about 2.5 moles of ATP for each mole of cytosolic NADH. Why does nature use the glycerol-phosphate shuttle, which yields only about 1.5 moles of ATP?arrow_forwardREFLECT AND APPLLY Show how the estimate of 33% efficiency of energy use in anaerobic glycolysis is derived.arrow_forward
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- REFLECT AND APPLY An enzyme catalyzes the formation of ATP from ADP and phosphate ion. What is its effect on the rate of hydrolysis of ATP to ADP and phosphate ion?arrow_forwardREFLECT AND APPLY Cytochrome oxidase and succinate-CoQ oxidoreductase are isolated from mitochondria and are incubated in the presence of oxygen, along with cytochrome c, coenzyme Q, and succinate. What is the overall oxidationreduction reaction that can be expected to take place?arrow_forwardREFLECT AND APPLY How does an increase in the ADP/ATP ratio affect the activity of isocitrate dehydrogenase?arrow_forward
- REFLECT AND APPLY In biochemistry, the exergonic process of converting glucose and oxygen to carbon dioxide and water in aerobic metabolism can be considered the reverse of photosynthesis, in which carbon dioxide and water are converted to glucose and oxygen. Do you expect both processes to be exergonic, both endergonic, or one exergonic and one endergonic? Why? Would you expect both processes to take place in the same way? Why?arrow_forwardREFLECT AND APPLY Two biochemistry students are about to use mitochondria isolated from rat liver for an experiment on oxidative phosphorylation. The directions for the experiment specify addition of purified cytochrome c from any source to the reaction mixture. Why is the added cytochrome c needed? Why does the source not have to be the same as that of the mitochondria?arrow_forwardREFLECT AND APPLY How does an increase in the NADH/NAD1 ratio affect the activity of pyruvate dehydrogenase?arrow_forward
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