Concept explainers
RECALL For the hypothetical reaction
the rate was experimentally determined to be
What is the order of the reaction with respect to A? With respect to B? What is the overall order of the reaction? Suggest how many molecules each of A and B are likely to be involved in the detailed mechanism of the reaction.
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Chapter 6 Solutions
Biochemistry
- REFLECT AND APPLY What do the following indicators tell you about whether a reaction can proceed as written? (a) The standard free-energy change is positive. (b) The free-energy change is positive. (c) The reaction is exergonic.arrow_forwardRECALL Is there a connection between the free-energy change for a reaction and its equilibrium constant? If there is a connection, what is it?arrow_forwardREFLECT AND APPLY A model is proposed to explain the reaction catalyzed by an enzyme. Experimentally obtained rate data fit the model to within experimental error. Do these findings prove the model?arrow_forward
- RECALL Show graphically how the reaction velocity depends on the enzyme concentration. Can a reaction be saturated with enzyme?arrow_forwardREFLECT AND APPLY Would you expect an irreversible inhibitor of an enzyme to be bound by covalent or by non-covalent interactions? Why?arrow_forwardREFLECT AND APPLY What is the relationship between a transition-state analog and the induced-fit model of enzyme kinetics?arrow_forward
- REFLECT AND APPLY Would you expect the reaction ATPADP+Pi to be accompanied by a decrease or increase in entropy? Why?arrow_forwardREFLECT AND APPLY A reaction at 23C has G=1kJmol1. Why might this reaction become spontaneous at 37C?arrow_forwardRECALL What is a suicide substrate? Why are they important?arrow_forward
- REFLECT AND APPLY Sulfanilamide and related sulfa drugs were widely used to treat diseases of bacterial origin before penicillin and more advanced drugs were readily available. The inhibitory effect of sulfanilamide on bacterial growth can be reversed by p-aminobenzoate. Suggest a mode of action for sulfanilamide.arrow_forwardREFLECT AND APPLY Other things being equal, what is a potential disadvantage of an enzyme having a very high affinity for its substrate?arrow_forwardREFLECT AND APPLY Comment on the energetics of protein folding in light of the information in this chapter.arrow_forward
- BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage Learning