1 SEM ACC W/RAVEN CARDED
12th Edition
ISBN: 9781265486297
Author: Raven
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Textbook Question
Chapter 52, Problem 1DA
Data analysis Two different genes have mutant alleles that cause this spotting
Expert Solution & Answer
Summary Introduction
To determine: The function of other gene product in spotting phenotype, if one gene encodes a signaling molecule.
Introduction: A mutation can be defined as a sudden change that occurs in the DNA sequence, during DNA replication. It can also be caused by exposure to specific chemicals or radiation. Mutation contributes to genetic variability.
Explanation of Solution
Neural crest cell under the surface of ectoderm differentiates into pigment cells of the skin. Survival and migration of these cellsare affected by a mutation in genes leads to white spotting in the skin. Two different genes have a mutant allele that causes the spotting phenotype in humans and mice. One gene act as a signaling molecule then the other is likely to be a receptor for the molecule.
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Students have asked these similar questions
4e. You also study the expression of 3 different mutants for this gene. For each mutant answer the
following:
Does this mutation change the sequence of the protein produced? Why or why not?
If it does change the sequence of protein be sure to write out the new sequence.
If it does not change the protein sequence, what effect (if any) would you expect it
to have on expression of the gene?
1
20
ORI
40
60
5'...TTCGAGCTCTCGTCGTCGAGATACGCGATGATATTACTGGTAATATGGGGATGCACTATC...3'
3' ...AAGCTCGAGAGCAGCAGCTCTATGCGCTACTATAATGACCATTATACCCCTACGTGATAG...5'
*
promoter
Match each example of mutation to the correct effect on function.
Hypomorphic
mutation
Hypermorphic
mutation
Antimorphic
mutation
Neomorphic
A deletion results in the loss of part of a protein and the protein
retains some of its normal activity.
A mutant allele makes a protein with increased cataytic activity.
A mutant form of a transcription factor binds new DNA sequences to
activate different genes.
A mutant from of a receptor protein interferes with the function of
the wild-type receptor through heterodimerization.
Protein P, normally stimulates apoptosis or cell death when activated.
Consider a cell with a mutation in one allele such that protein P is always expressed
and active, while the other allele of gene P is deleted.
Which of the following is true for this cell?
Gene P is a proto-oncogene, and the phenotype of the cell is transformed.
Gene P is a proto-oncogene, and the phenotype of the cell is not transformed.
Gene P is a tumor suppressor gene, and the phenotype of the cell
is not transformed
Gene P is a tumor suppressor gene, and the phenotype of the cell is transformed
로
Chapter 52 Solutions
1 SEM ACC W/RAVEN CARDED
Ch. 52.1 - Describe the events involved in fertilization.Ch. 52.1 - Prob. 2LOCh. 52.2 - Prob. 1LOCh. 52.2 - Prob. 2LOCh. 52.2 - Prob. 3LOCh. 52.3 - Prob. 1LOCh. 52.3 - Compare gastrulation in different animals.Ch. 52.3 - Name the extraembryonic membranes in amniotes.Ch. 52.4 - Prob. 1LOCh. 52.4 - Prob. 2LO
Ch. 52.4 - Prob. 3LOCh. 52.5 - Prob. 1LOCh. 52.5 - Explain the function of the organizer.Ch. 52.5 - Distinguish between primary and secondary...Ch. 52.6 - Describe the major developmental events in the...Ch. 52.6 - Explain the role of the placenta.Ch. 52.6 - Prob. 3LOCh. 52 - Data analysis Two different genes have mutant...Ch. 52 - Prob. 1IQCh. 52 - Prob. 1UCh. 52 - Which of the following plays the greatest role in...Ch. 52 - Gastrulation is a critical event during...Ch. 52 - Gastrulation in a mammal would be most similar to...Ch. 52 - Prob. 5UCh. 52 - Of the following processes, which occurs last? a....Ch. 52 - Which of the following would qualify as a...Ch. 52 - Prob. 1ACh. 52 - In the Spemann experiment, when the dorsal lip is...Ch. 52 - Suppose that a burst of electromagnetic radiation...Ch. 52 - Prob. 4ACh. 52 - Drug or alcohol exposure during which of the...Ch. 52 - Axis formation in amniotic embryos could be...Ch. 52 - Prob. 1SCh. 52 - You look up from your studying to see your dog,...Ch. 52 - Why doesnt a woman menstruate while she is...Ch. 52 - Spemann and Mangold were able to demonstrate that...
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- Cap, EA1, and Sap are all genes and are also proteins. For each gene, what gene product is encoded and where is the gene aka literal DNA sequence and located physically in the cell? I need help for each one cap what gene product is encoded and location Ea1 what gene product is encoded and location Sap what gene product is encoded and locationarrow_forwardGenetics Question about epigenetic mechanisms. This is the only question that I just do not understand. Which column does each of these go in and they can used multiple times or not at all.arrow_forwardYour friend sends you two cancerous cell lines to examine and determine possible mutations. The results are shown below: Cell Line Mutation WT none (wild type DNA) 1 a deletion at the same region on both copies of chromosome 4 a point mutation in a gene on only one copy of chromosome 7 Based on this data, what type of geńe is mutated in each of the cell lines? Select all that apply O Cell line 2 has a mutation in an oncogene Cell line 1 has a mutation in a tumor suppressor gene Cell line 1 has a mutation in an proto-oncogene Cell line 2 has a mutation in a tumor suppressor genearrow_forward
- Your friend sends you two cancerous cel| lines to examine and determine possible mutations. The results are shown below: Cell Line Mutation WT none (wild type DNA) 1 a deletion at the same region on both copies of chromosome 4 2 a point mutation in a gene on only one copy of chromosome 7 You learn that cell line 2 is a breast cancer cell line that expresses a mutant version of a receptor protein called KIT. Based on this data, which of the following is true ? Select all that apply Activation of KIT promotes progression through the cell cycle Activation of KIT releases an inhibition of a cyclin Activation of KIT causes cells to enter GO O Activation of KIT promotes cells to undergo apoptosisarrow_forwardWhen chromatin is condensed, transcription cannot happen. Why not? RNA cannot access the promoter region of the gene DNA helicase cannot access the RNA strand RNA polymerase cannot access the DNA strand Transcription factors cannot access the termination region of the genearrow_forwarde. You also study the expression of 2 different mutants for this gene. For each mutant answer the following: Does this mutation change the sequence of the protein produced? Why or why not? o If it does change the sequence of protein be sure to write out the new sequence. If it does not change the protein sequence, what effect (if any) would you expect it to have on expression of the gene? 1 20 ORI 40 60 5'..TTCGAGCTCTCGTCGTCGAGATACGCGATGATATTACTGGTAATATGGGGATGCACTATC...3’ 3' ...AAGCTCGAGAGCAGCAGCTCTATGCGCTACTATAATGACCATTATACCCCTACGTGATAG...5' promoter i. Mutant A has a single base pair substitution with the T/A being replaced with C/G base pair at position 35 (position denoted by the * in the sequence above).arrow_forward
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