BIOLOGY
12th Edition
ISBN: 9781260169614
Author: Raven
Publisher: RENT MCG
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Textbook Question
Chapter 52, Problem 1DA
Data analysis Two different genes have mutant alleles that cause this spotting
Expert Solution & Answer
Summary Introduction
To determine: The function of other gene product in spotting phenotype, if one gene encodes a signaling molecule.
Introduction: A mutation can be defined as a sudden change that occurs in the DNA sequence, during DNA replication. It can also be caused by exposure to specific chemicals or radiation. Mutation contributes to genetic variability.
Explanation of Solution
Neural crest cell under the surface of ectoderm differentiates into pigment cells of the skin. Survival and migration of these cellsare affected by a mutation in genes leads to white spotting in the skin. Two different genes have a mutant allele that causes the spotting phenotype in humans and mice. One gene act as a signaling molecule then the other is likely to be a receptor for the molecule.
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Students have asked these similar questions
4e. You also study the expression of 3 different mutants for this gene. For each mutant answer the
following:
Does this mutation change the sequence of the protein produced? Why or why not?
If it does change the sequence of protein be sure to write out the new sequence.
If it does not change the protein sequence, what effect (if any) would you expect it
to have on expression of the gene?
1
20
ORI
40
60
5'..TTCGAGCTCTCGTCGTCGAGATACGCGATGATATTACTGGTAATATGGGGATGCACTATC...3’
3'...AAGCTCGAGAGCAGCAGCTCTATGCGCTACTATAATGACCATTATACCCCTACGTGATAG...5’
promoter
i. Mutant A has a single base pair substitution with the T/A being replaced with C/G base pair at
position 35 (position denoted by the * in the sequence above).
ii. Mutant B has a 2 G/C pairs inserted between position 19 and 20 (position denoted by the ^ in
the sequence above).
Please help me with the question below - it is based on Cellular Biology.
Star eye
A peculiar eye condition known as "star” is manifested as a dominant gene in Drosophila. Its recessive allele R* produces the normal eye of wild type. The expression of R can be suppressed by the dominant allele of another locus, Ru-R. Ru-R*, as the recessive allele of the said locus, has no inhibitory effect on R*.
When a normal-eyed male of genotype Ru-R Ru-R RR is crossed to a homozygous wild-type female of genotype Ru-R* Ru-R* R*R*, what phenotypic ratio is expected in the F2?
Chapter 52 Solutions
BIOLOGY
Ch. 52.1 - Describe the events involved in fertilization.Ch. 52.1 - Prob. 2LOCh. 52.2 - Prob. 1LOCh. 52.2 - Prob. 2LOCh. 52.2 - Prob. 3LOCh. 52.3 - Prob. 1LOCh. 52.3 - Compare gastrulation in different animals.Ch. 52.3 - Name the extraembryonic membranes in amniotes.Ch. 52.4 - Prob. 1LOCh. 52.4 - Prob. 2LO
Ch. 52.4 - Prob. 3LOCh. 52.5 - Prob. 1LOCh. 52.5 - Explain the function of the organizer.Ch. 52.5 - Distinguish between primary and secondary...Ch. 52.6 - Describe the major developmental events in the...Ch. 52.6 - Explain the role of the placenta.Ch. 52.6 - Prob. 3LOCh. 52 - Data analysis Two different genes have mutant...Ch. 52 - Prob. 1IQCh. 52 - Prob. 1UCh. 52 - Which of the following plays the greatest role in...Ch. 52 - Gastrulation is a critical event during...Ch. 52 - Gastrulation in a mammal would be most similar to...Ch. 52 - Prob. 5UCh. 52 - Of the following processes, which occurs last? a....Ch. 52 - Which of the following would qualify as a...Ch. 52 - Prob. 1ACh. 52 - In the Spemann experiment, when the dorsal lip is...Ch. 52 - Suppose that a burst of electromagnetic radiation...Ch. 52 - Prob. 4ACh. 52 - Drug or alcohol exposure during which of the...Ch. 52 - Axis formation in amniotic embryos could be...Ch. 52 - Prob. 1SCh. 52 - You look up from your studying to see your dog,...Ch. 52 - Why doesnt a woman menstruate while she is...Ch. 52 - Spemann and Mangold were able to demonstrate that...
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- Enhanced Spatial Learning Ability in Mice Engineered to Carry an Autism Mutation Autism is a neurobiological disorder with symptoms that include impaired social interactions and repetitive, stereotyped patterns of behavior. Around 10 percent of autistic people also have an extraordinary skill or talent such as greatly enhanced memory. Mutations in the gene for neuroligin 3, an adhesion protein that connects brain cells, have been associated with autism. One of these mutations is called R451C because the altered gene encodes a protein with an amino acid substitution: a cysteine (C) instead of an arginine (R) in position 451. In 2007, Katsuhiko Tabuchi and his colleagues introduced the R451C mutation into the neuroligin 3 gene of mice. The researchers discovered that the genetically modified mice had impaired social behavior and superior spatial learning ability. Spatial learning in mice is tested with a water maze, which consists of a small platform submerged a bit below the surface or a pool of water so it is invisible to a swimming mouse. Mice do not particularly enjoy swimming, so they try to locate the hidden platform as quickly as they can. When tested again later, they remember the platforms location by checking visual cues around the edge or the pool. How quickly they remember is a measure of their spatial learning ability. FIGURE 15.14 shows some or Tabuchis result. FIGURE 15.14 Spatial learning ability in mice. Mice with a mutation in neuroligin 3 (R451C) were tested for learning performance: as compared with unmodified (wild-type) mice. Did the modified or the unmodified mice learn the location of the platform faster in the first test?arrow_forwardProtein P, normally stimulates apoptosis or cell death when activated. Consider a cell with a mutation in one allele such that protein P is always expressed and active, while the other allele of gene P is deleted. Which of the following is true for this cell? Gene P is a proto-oncogene, and the phenotype of the cell is transformed. Gene P is a proto-oncogene, and the phenotype of the cell is not transformed. Gene P is a tumor suppressor gene, and the phenotype of the cell is not transformed Gene P is a tumor suppressor gene, and the phenotype of the cell is transformed 로arrow_forwardCap, EA1, and Sap are all genes and are also proteins. For each gene, what gene product is encoded and where is the gene aka literal DNA sequence and located physically in the cell? I need help for each one cap what gene product is encoded and location Ea1 what gene product is encoded and location Sap what gene product is encoded and locationarrow_forward
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