Chapter 52, Problem 1DA

Data analysis Two different genes have mutant alleles that cause this spotting phenotype. One gene encodes a signaling molecule. What Is the likely function of the other gene product?

Summary Introduction

To determine: The function of other gene product in spotting phenotype, if one gene encodes a signaling molecule.

Introduction: A mutation can be defined as a sudden change that occurs in the DNA sequence, during DNA replication. It can also be caused by exposure to specific chemicals or radiation. Mutation contributes to genetic variability.

Explanation of Solution

Neural crest cell under the surface of ectoderm differentiates into pigment cells of the skin. Survival and migration of these cellsare affected by a mutation in genes leads to white spotting in the skin. Two different genes have a mutant allele that causes the spotting phenotype in humans and mice. One gene act as a signaling molecule then the other is likely to be a receptor for the molecule.