The significance of the fact that sodium ion/potassium ion (Na + /K + ) exchanger cause the secretion of two K + ions for every three Na + ions, it reabsorbs in the tubule cells. Introduction: Aldosterone is produced in response to the angiotensin and helps in maintaining blood pressure and reabsorbs sodium ions from the renal tubules. Aldosterone also have the roles in excreting potassium ions out of the cells.

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Chapter 51.6, Problem 2R

Summary Introduction

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The significance of the fact that sodium ion/potassium ion (Na⁺/K⁺) exchanger cause the secretion of two K⁺ ions for every three Na⁺ ions, it reabsorbs in the tubule cells.

Introduction:

Aldosterone is produced in response to the angiotensin and helps in maintaining blood pressure and reabsorbs sodium ions from the renal tubules. Aldosterone also have the roles in excreting potassium ions out of the cells.

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Drugs that increase urine flow (diuretic drugs) are often employed in the treatment of hypertension (high blood pressure) or other disease states. Three physiological categories of such drugs are ones that (i) function as loop diuretics, (ii) inhibit the action of aldosterone, and (iii) block Na+ channels in the collecting ducts. Explain why each of these categories would be expected to increase Na+ excretion and urine flow.

Which is TRUE of the RAAS pathway? angiotensin Il directly leads to vasoconstriction and stimulates aldosterone which promotes Na+ reabsorption at the cortical collecting duct ANP stimulates the RAAS pathway, while ADH/vasopressin inhibits the RAAS pathway increased plasma volume directly puts extra pressure on the afferent arteriole and indirectly increases pressure in the distal tubule, both of which lead to stimulation of renin release angiotensin Il promotes activation of the parasympathetic system which decreases GFR low plasma Na+ is sensed by the proximal tubule and triggers release of renin from JGA cells

Drugs that increase urine flow (diuretic drugs) are oftenemployed in the treatment of hypertension (high blood pressure)or other disease states. Three physiological categories of suchdrugs are ones that (i) function as loop diuretics, (ii) inhibitthe action of aldosterone, and (iii) block Na+ channels in thecollecting ducts. Explain why each of these categories wouldbe expected to increase Na+ excretion and urine flow. (Hint:Rereading the section on hormones at the end of Chapter 28might prove helpful.)