Chapter 5, Problem 5.61P

Interpretation Introduction

Interpretation: The relation between the compounds A and B-E is to be determined.

Concept introduction: The stereogenic centers with $R,S$ configuration are assigned according to Cahn-Ingold-Prelog rules. According to these rules, the substituents attached to stereogenic centers are given priority. On moving from higher priority to lower priority substituent in clockwise direction, the compound is assigned with $R$ configuration. On moving from higher priority to lower priority substituent in anticlockwise direction, the compound is assigned with $S$ configuration. Enantiomer of a compound has opposite configuration at stereogenic centers. Diastereomers of a compound have at least one stereogenic centre with same configuration and at least one with opposite configuration.