Concept explainers
To review:
The results of the HIV (human immunodeficiency virus) experiment and compare them with the Ebola virus (EBOV) experiment.
Introduction:
Ebola virus can lead to severe and fatal hemorrhagic fever in the human beings. The disease caused is known as Ebola virus disease. HIV is the subgroup of retrovirus (lentivirus) that leads to AIDS (acquired immunodeficiency syndrome). HIV utilizes CD4 (cluster of differentiation 4) receptor in order to enter the T helper cells. The cells that have free and unbound CD4 on their surface will be infected by the HIV. CD4 is a membrane protein that HIV utilizes to enter the cells. Similarly, researchers have identified many surface proteins that may work as a virus receptor for the EBOV. The figure below shows the experiment that was performed using HIV virus.
Experiment: One hundred sixty identical samples of T helper cells were grown in the culture. Different antibodies were then added into each sample of the cells. The antibody inhibits the specific membrane protein. A constant number of virions were then added to the samples followed by the incubation process under the conditions that are optimal for the viruses to enter.
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