Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 3, Problem 31P
The cell cycle operates in the same way in all eukaryotes, from single-celled yeast to humans, and all share numerous genes whose functions are essential for the normal progression of the cycle. Discuss why you think this is the case.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Why do eukaryotic cells need to go through the elaborate procedure of mitosis rather than simply dividing during interphase? Select as many answers as apply.
1.Daughter cells must be genetically identical to the mother cell, for homeostasis and ordered tissue growth.
2.Bivalent chromosomes must condense and be separated in an orderly fashion, to allow equal distribution of copies into daughter cells
3.Physically dividing the nucleus during interphase would likely lead to gross chromosome breakage and highly unequal assortment of genetic information into daughter cells.
4.Dividing the nucleus during interphase would have the same outcome as mitosis
5.Daughter cells must have half the number of chromosomes after mitosis than the mother cells
6.The homologous pairs of chromosomes need to be separated, to ensure copies go to the daughter cells.
Explain why we can say that M-phase of the cell-cycle is triggered by a positive feedback loop.
a) What would the consequences be if cohesins were working normally but condensins were not? and b) what stage of the cell cycle would this cause problems in?
Why is it important for the centrosome to duplicate during G1-G2 (interphase) before M phase?
The kinetochores serve as a link between the sister chromatids and the microtubules attached to the mitotic spindle. a) How are microtubules still able to exhibit dynamic instability after they are bound to the sister chromatids and b) why is this important to mitosis?
As the name suggests, the Anaphase-promoting-complex (APC), promotes the 4th phase of mitosis by separating the sister chromatids so they can travel to separate poles of the cell, and prevents them from being re-zipped together. Describe how APC does these two things (Hint: one involves M-cyclin and the other involves…
One approach to studying the regulation of cell cycle progression (particularly in an era when genetic and molecular biology manipulations were less readily accomplished in mammalian cells) was to use treatments that induced cells to fuse and then monitor the behavior of the two nuclei in the resulting cell. The figure below depicts data from one such study. The investigators did preliminary work to produce populations of cells that were synchronized in various stages of the cell cycle (G1, S, or G2 in the examples shown below). They then fused the cells in different combinations and monitored subsequent events in each of the nuclei. For purposes of this question, we will pay particular attention to what occurred in the nucleus that came from the cell in G1. In one experiment (I), cells in the G1 and S phases were fused. That event caused the nucleus from the G1 cell to very quickly enter the S phase (sooner than it would otherwise have done so). In contrast, in a second experiment…
Chapter 3 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 3 - Examine the following diagrams of cells from an...Ch. 3 - Our closest primate relative, the chimpanzee, has...Ch. 3 -
3. In a test of his chromosome theory of...Ch. 3 - Cohesion between sister chromatids, as well as...Ch. 3 - 5. The diploid number of the hypothetical animal...Ch. 3 - 6. An organism has alleles R1 and R2 on one pair...Ch. 3 - Explain how the behavior of homologous chromosomes...Ch. 3 - 8. Suppose crossover occurs between the homologous...Ch. 3 -
9. Alleles A and a are on one pair of autosomes,...Ch. 3 - Prob. 10P
Ch. 3 - Describe the role of the following structures or...Ch. 3 - A womans father has ornithine transcarbamylase...Ch. 3 - In humans, hemophilia A (OMIM 306700) is an...Ch. 3 -
14. A wild-type male and a wild-type female...Ch. 3 - 15. A woman with severe discoloration of her tooth...Ch. 3 - 16. In a large metropolitan hospital, cells from...Ch. 3 - In cats, tortoiseshell coat color appears in...Ch. 3 - 18. The gene causing Coffin–Lowry syndrome (OMIM...Ch. 3 - 19. Four eye-color mutants in Drosophila—apricot,...Ch. 3 - 20. For each pedigree shown,
a. Identify which...Ch. 3 - 21. Use the blank pedigrees provided to depict...Ch. 3 - 22. Figure 3.22 (page 89) illustrates reciprocal...Ch. 3 - 23. In fruit flies, yellow body (y) is recessive...Ch. 3 - 24. In a species of fish, a black spot on the...Ch. 3 - LeschNyhan syndrome (OMIM 300322) is a rare...Ch. 3 - 26. In humans, SRY is located near a...Ch. 3 - 27. In an 1889 book titled Natural Inheritance...Ch. 3 - 28. In Drosophila, the X-linked echinus eye...Ch. 3 - 29. A wild-type Drosophila male and female are...Ch. 3 - 30. Drosophila has a diploid chromosome number of...Ch. 3 - The cell cycle operates in the same way in all...Ch. 3 - 33. Form a small discussion group and decide on...Ch. 3 - 34. Duchenne muscular dystrophy (DMD; OMIM 310200)...Ch. 3 - Prob. 35P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Which phases of the cell cycle is generally the longest in the cells of a mature eukaryote? What steps make it longest phase?arrow_forwardFigure 3.7 shows a syncytial Drosophila embryo, a single large cell that can contain hundreds or even thousands of nuclei. Each round of nuclear division can occur rapidly, sometimes as quickly as 10 minutes. These rapid divisions do not require all the stages seen in a normal cell cycle. Which stages (G1, S, G, mitosis, cytokinesis) are dispensable and which are not? Explain.arrow_forwardOne approach to studying the regulation of cell cycle progression (particularly in an era when genetic and molecular biology manipulations were less readily accomplished in mammalian cells) was to use treatments that induced cells to fuse and then monitor the behavior of the two nuclei in the resulting cell. The figure below depicts data from one such study. The investigators did preliminary work to produce populations of cells that were synchronized in various stages of the cell cycle (G1, S, or G2 in the examples shown below). They then fused the cells in different combinations and monitored subsequent events in each of the nuclei. For purposes of this question, we will pay particular attention to what occurred in the nucleus that came from the cell in G1. In one experiment (I), cells in the G1 and S phases were fused. That event caused the nucleus from the G1 cell to very quickly enter the S phase (sooner than it would otherwise have done so). In contrast, in a second experiment…arrow_forward
- For an organism with 3 pairs of chromosomes (6 total chromosomes, 2n = 6), draw chromosome diagrams for the following phases of the mitotic cell cycle: G1 of interphase, prophase, metaphase, anaphase & telophase. Be sure to draw the correct number of chromosomes and the correct number of chromatids per chromosome. Use a different color to represent each chromosome type (for example, use blue to indicate all copies of chromosome 1, red for all copies of chromosome 2, & green for all copies of chromosome 3).arrow_forwardPassage of cells from G1 through R to S depends on the interaction of various signal molecules, proteins and enzymes which regulate the cell cycle. Imagine I have just induced a mutation in a cell line which prevents the breakdown of the cyclin molecule we discussed. Which of the following events do you predict will happen? circle all that apply Select one or more: a. Uncontrolled cell replication may result b. Retinoblastoma protein will be continuously active c. The cells will be stuck in G1 phase d. The cells will begin to replicate their DNA e. Cyclin dependent kinase (Cdk) will be continuously activearrow_forwardhow many sister chromatids, chromosomes and homologous chromosome pairs are in each human eukaryotic cell under different phases of the cell cycle? Briefly describe what is hapenning in each phase.arrow_forward
- Which of the following statements are true regarding mitosis in humans? 23 pairs of homologous chromosomes are separated four haploid gametes are produced in males 46 pairs of homologous chromosomes are separated two genetically identical daughter cells are produced 23 pairs of sister chromatids are separated 46pairs of sister chromatids are separated 1 haploid gamete and 2 polar bodies are produced in femalesarrow_forwardWhat are the three protein families that regulate the cell cycle? give an example for each:arrow_forward4) Describe in detail how p53 and MDM2 regulate cell division in a normal, healthy cell. You should describe 1) how these proteins cooperate to allow a cell to go through the cell cycle, 2) how they cooperate to stop the cell cycle, and 3) how they allow the cell cycle to continue again after having stopped it initially. You may use point form if you want.arrow_forward
- It is often useful for scientists to study a population of cells that are all at the same stage of the cell cycle. For example, the discovery of cyclins and Cdks was enabled by studying frog eggs that divided synchronously after fertilization; extracts from the embryos were thus representative of the cell-cycle stage at which the extract was made. Researchers have devised means to synchronize asynchronous populations of cultured cells. For example, serum starvation deprives cells of mitogens and blocks cells in the Go/G₁ phase of the cell cycle. Another method involves gently shaking culture flasks and harvesting the cells that release from the substratum. In what stage of the cell cycle are these cells most likely to be? Choose one: • Sphase G2 phase M phase G1 phase Aarrow_forwardThe figure above shows a metaphase in which one chromosome is only connected to the spindle by a single kinetochore, thus the sister chromatids may not separate correctly during anaphase. which of the following statement/s is/are correct;arrow_forwardIn class, we talked about flow cytometry which allows scientists to determine what stage of the cell cycle cells are in by measuring their DNA content. Draw what the graph would look like for the mutant below at a 0-time point when there are 1000 cells total, with 5000 cells in G1, 350 cells in M and G2, and 150 cells in S phase. And then a graph of 1 hour later when the cells should have competed for mitosis: → loss of function of cdc25arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Biology (MindTap Course List)BiologyISBN:9781305112100Author:Cecie Starr, Beverly McMillanPublisher:Cengage Learning
Human Biology (MindTap Course List)
Biology
ISBN:9781305112100
Author:Cecie Starr, Beverly McMillan
Publisher:Cengage Learning
The Cell Cycle and its Regulation; Author: Professor Dave Explains;https://www.youtube.com/watch?v=eqJqhA8HSJ0;License: Standard YouTube License, CC-BY
Cell Division - Mitosis and Meiosis - GCSE Biology (9-1); Author: Mr Exham Biology;https://www.youtube.com/watch?v=w7vp_uRA8kw;License: Standard YouTube License, CC-BY