Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Textbook Question
Chapter 3, Problem 21P
Use the blank pedigrees provided to depict transmission of (a) an X-linked recessive trait and (b) an X-linked dominant trait, by filling in circles and squares to represent individuals with the trait of interest. Give genotypes for each person in each pedigree. Carefully design each transmission pattern so that pedigree (a) cannot be confused with autosomal recessive transmission and pedigree (b) cannot be confused with autosomal dominant transmission. Identify the transmission events that eliminate the possibility of autosomal transmission for each pedigree.
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X‑linked, recessive diseases, such as hemophilia, are extremely rare in the population. However, many women are carriers and show no sign of the disease. The pedigree illustrates the inheritance of an X‑linked, recessive disease.
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Albinism in humans is inherited as a simple recessive trait.Determine the genotypes of the parents and offspring for the following families. When two alternative genotypes are possible,list both.(a) Two parents without albinism have five children, four withoutalbinism and one with albinism.(b) A male without albinism and a female with albinism havesix children, all without albinism.
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Chapter 3 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 3 - Examine the following diagrams of cells from an...Ch. 3 - Our closest primate relative, the chimpanzee, has...Ch. 3 -
3. In a test of his chromosome theory of...Ch. 3 - Cohesion between sister chromatids, as well as...Ch. 3 - 5. The diploid number of the hypothetical animal...Ch. 3 - 6. An organism has alleles R1 and R2 on one pair...Ch. 3 - Explain how the behavior of homologous chromosomes...Ch. 3 - 8. Suppose crossover occurs between the homologous...Ch. 3 -
9. Alleles A and a are on one pair of autosomes,...Ch. 3 - Prob. 10P
Ch. 3 - Describe the role of the following structures or...Ch. 3 - A womans father has ornithine transcarbamylase...Ch. 3 - In humans, hemophilia A (OMIM 306700) is an...Ch. 3 -
14. A wild-type male and a wild-type female...Ch. 3 - 15. A woman with severe discoloration of her tooth...Ch. 3 - 16. In a large metropolitan hospital, cells from...Ch. 3 - In cats, tortoiseshell coat color appears in...Ch. 3 - 18. The gene causing Coffin–Lowry syndrome (OMIM...Ch. 3 - 19. Four eye-color mutants in Drosophila—apricot,...Ch. 3 - 20. For each pedigree shown,
a. Identify which...Ch. 3 - 21. Use the blank pedigrees provided to depict...Ch. 3 - 22. Figure 3.22 (page 89) illustrates reciprocal...Ch. 3 - 23. In fruit flies, yellow body (y) is recessive...Ch. 3 - 24. In a species of fish, a black spot on the...Ch. 3 - LeschNyhan syndrome (OMIM 300322) is a rare...Ch. 3 - 26. In humans, SRY is located near a...Ch. 3 - 27. In an 1889 book titled Natural Inheritance...Ch. 3 - 28. In Drosophila, the X-linked echinus eye...Ch. 3 - 29. A wild-type Drosophila male and female are...Ch. 3 - 30. Drosophila has a diploid chromosome number of...Ch. 3 - The cell cycle operates in the same way in all...Ch. 3 - 33. Form a small discussion group and decide on...Ch. 3 - 34. Duchenne muscular dystrophy (DMD; OMIM 310200)...Ch. 3 - Prob. 35P
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- Using the pedigree, assume that the disease is caused by an autosomal dominant allele, R. Give the genotype of the following individuals: (a) III-4 (the girl at lower right) (b) II-3 (the girl’s mother) (c) II-4 (the girl’s father)arrow_forwardIn humans, the genetic disease cystic fibrosis is caused by a recessive allele (a). The normal (healthy) allele is dominant (A). What is the genotype of someone who has cystic fibrosis? What are the two different genotypes that a healthy person could have? If two people were both heterozygous for the cystic fibrosis gene, what fraction of their children would be likely to have this disease? Hint: Draw a Punnett square to figure it out.arrow_forwardPlease consider the following pedigree. Assume that people who marry in to the family do not carry the allele. Assume complete penetrance. I II III 3 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Based strictly on the characteristic patterns of inheritance that define the four different options in (a), give a definitive motivation for the most likely mode of inhertance.arrow_forward
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