Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 29, Problem 18P
Interpretation Introduction
Interpretation:
The catalytic mechanism for topoisomerase II in the presence of AMP-PNP needs to be explained.
Concept introduction:
AMP-PNP acts as a competitive inhibitor to ATP. One strand of DNA twists around the other and it is done in the right-hand direction which is known as DNA super coiling.Topoisomerase can remove super coiling.
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