Explanation Drugs are molecules which are taken from an external source to change the normal functioning of the body. Drugs bind with receptors showing an increased or decreased effect. There are two types of drugs and they are agonist and antagonist. Agonists are chemical substance that binds with a receptor so that it activates the receptor for producing or prolonging its normal biochemical response. Antagonists are chemical substance that binds with a receptor so that it blocks or inhibits the normal biochemical response of a particular receptor. Dopamine is a neurotransmitter has a key role in the brain...

Fundamentals of General, Organic, and Biological Chemistry (8th Edition)

8th Edition

ISBN: 9780134015187

Author: John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson

Publisher: PEARSON

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Question

Chapter 28, Problem 28.78AP

Interpretation Introduction

Interpretation:

Chlorpromazine is whether agonist or antagonist has to be determined.

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Chapter 28, Problem 28.77AP

Chapter 28, Problem 28.79AP

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In schizophrenia, the neurons affected by dopamine are overstimulated. This condition is treated with drugs like chlorpromazine (Thorazine), which bind to the affected receptors and inhibit the dopamine signal. Does chlorpromazineact as an agonist or antagonist?

Chlorpromazine and Bromocriptine both have the affinity in the dopamine receptors of the Central Nervous System, Chlorpromazine is use to treat schizophrenia and psychosis whereas Bromocriptine is use to treat parkinson’s disease. Explain the action of these drugs in the dopamine receptor and why they have different effects and clinical use, knowing that they both act on the dopamine receptors.

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Chapter 28 Solutions

Fundamentals of General, Organic, and Biological Chemistry (8th Edition)

Ch. 28.1 - While thinking about how a messenger molecule and...Ch. 28.2 - Prob. 28.2P Ch. 28.2 - Prob. 28.3P Ch. 28.2 - Prob. 28.4P Ch. 28.3 - Prob. 28.5P Ch. 28.3 - Prob. 28.6KCP Ch. 28.4 - Prob. 28.7P Ch. 28.4 - Look at the structure of thyroxine shown earlier...Ch. 28.4 - Prob. 28.1CIAP Ch. 28.4 - Prob. 28.2CIAP

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Chlorpromazine is whether agonist or antagonist has to be determined.

Solution Summary: The author explains that Chlorpromazine is an antagonist. Agonists bind with receptors, while antagonists block or inhibit the normal biochemical response of a particular receptor.

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Interpretation: Chlorpromazine is whether agonist or antagonist has to be determined.

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Chapter 28 Solutions

Interpretation:

Chlorpromazine is whether agonist or antagonist has to be determined.