Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Videos
Textbook Question
Chapter 28, Problem 19P
Figure 28.11 depicts the eukaryotic cell cycle. Many cell types “exit� the cell cycle and don’t divide for prolonged periods, a state termed
a. In what stage of the cell cycle do you suppose a cell might be when it exits the cell cycle and enters
b. The cell cycle is controlled by checkpoints, cyclins, and CDKs. Describe how biochemical events involving cyclins and CDKs might control passage of a dividing cell through the cell cycle.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
1. (a) Describe the generalized model of the cell cycle. Demonstrate how cyclins and cyclin-dependent kinases can regulate the cell cycle.
(b). Describe three ways in which cells lose their ability to regulate their growth to become cancerous.
BPA is a chemical compound that has historically been used in themanufacture of plastic products. However, cells often mistake BPAcompounds for hormones that accelerate the cell cycle. Because ofthis, BPA is associated with an increased risk of certain cancers.
Question: How might BPA interact with the cell cycle and its checkpoints?
Which of the following is least likely to result in the formation of a cancerous cell?
A Dysfunction results in the permanent activation of a cell division pathway in the absence
of the appropriate ligand.
B
с
D
Separation of chromatids during mitosis occurs without all centromeres being attached
to spindle fibers from both poles.
A dysfunction in a cell cycle checkpoint prevents a cell from entering the S phase.
A dysfunction causes the inability to produce cancer-suppressing proteins.
Chapter 28 Solutions
Biochemistry
Ch. 28 - Semiconservative or Conservative DNA Replication...Ch. 28 - The Enzymatic Activities of DNA Polymerase I (a)...Ch. 28 - Multiple Replication Forks in E. coli I Assuming...Ch. 28 - Multiple Replication Forks in E. coli II On the...Ch. 28 - Molecules of DNA Polymerase III per Cell vs....Ch. 28 - Number of Okazaki Fragments in E. coli and Human...Ch. 28 - The Roles of Helicases and Gyrases How do DNA...Ch. 28 - Human Genome Replication Rate Assume DNA...Ch. 28 - Heteroduplex DNA Formation in Recombination From...Ch. 28 - Homologous Recombination, Heteroduplex DNA, and...
Ch. 28 - Prob. 11PCh. 28 - Prob. 12PCh. 28 - Chemical Mutagenesis of DNA Bases Show the...Ch. 28 - Prob. 14PCh. 28 - Recombination in Immunoglobulin Genes If...Ch. 28 - Helicase Unwinding of the E. coli Chromosome...Ch. 28 - Prob. 17PCh. 28 - Functional Consequences of Y-Family DNA Polymerase...Ch. 28 - Figure 28.11 depicts the eukaryotic cell cycle....Ch. 28 - Figure 28.41 gives some examples of recombination...Ch. 28 - Prob. 21PCh. 28 - Prob. 22P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Biologists have long been interested in the effects of radiation on cells. In one experiment, researchers examined the effect of radium on mitosis of chick embryo cells growing in culture. A population of experimental cells was examined under the microscope for the number of cells in telophase (as a measure of mitosis occurring) before, during, and after exposure to radium. The results are shown in the Figure. What is the effect of radium exposure on mitosis? Source: R. G. Canti and M. Donaldson. 1926. The effect of radium on mitosis in vitro. Proceedings of the Royal Society of London, Series B, Containing Papers of a Biological Character 100:413419.arrow_forwardThe process of cellular reproduction or divisions is a heavily regulated process for a number of different reasons. In the case of the eukaryotic cell there are a number of different checkpoints that a cell must pass before it can continue on. Please explain what those checkpoints are looking for and where those checkpoints are in the cell cycle. If a cell doesn’t pass any of these checkpoints what happens to those cells?arrow_forwardWhat cellular mechanism(s) ensure that passage through the cell cycle is unidirectional and irreversible? What molecular machinery underlies these mechanism(s)?arrow_forward
- Normal Cell Cycle Describe the cell cycle using the following words: 1. Interphase 2. G1 1 3. G2 4. S phase 5. Mphase (mitosis) 6. Prophase 7. Metaphase 8. Anaphase 9. Telophase 10. Cytokinesis 11. Apoptosis 12. Check Points feedbackarrow_forwardBPA is a chemical compound that has historically been used in themanufacture of plastic products. However, cells often mistake BPAcompounds for hormones that accelerate the cell cycle. Because ofthis, BPA is associated with an increased risk of certain cancers. Question: Why do you think that very small concentrations of BPA mighthave a large effect on the cell?arrow_forwardPassage of cells from G1 through R to S depends on the interaction of various signal molecules, proteins and enzymes which regulate the cell cycle. Imagine I have just induced a mutation in a cell line which prevents the breakdown of the cyclin molecule we discussed. Which of the following events do you predict will happen? circle all that apply Select one or more: a. Uncontrolled cell replication may result b. Retinoblastoma protein will be continuously active c. The cells will be stuck in G1 phase d. The cells will begin to replicate their DNA e. Cyclin dependent kinase (Cdk) will be continuously activearrow_forward
- Cell growth and division occurin a regular cycle. This cycle is divided into four phases: G1, S, G2, and M. The diagram sh ows this cycle, alongwith events that occur in each phase. Follow the prompts below. v Color the phase in which most cell growth occurs BLUE v Color the phase in which DNA replication occurs RED. v Color the phase in which preparation for mitosis G2 occurs in YELLOW. v Color the phase in which mitosis and cytokinesis occur in GREEN. 4. Which three phases make upinterphase? GI M 5. Which of the following best describes cancer? Circle the correct answer. uncontrolled cell growth cells stop growing 6. If a dog has 72 chromosomes in a SOMATIC cell, how many chromosomes will its daughter cells have after meiosis_? mitosis_? P.arrow_forward"Agent V" is the name of an anticancer (chemotherapy) drug. This drug works against cancer cells by inhibiting the formation of microtubules in sensitive cells. Consider a cell that is sensitive to agent V (in other words, agent V is effective at stopping growth of this cell). Based on this information, agent V would cause the cell to be frozen at which of the major cell cycle checkpoints (G1, G2 or M checkpoint)? Explain your answer in 2- 4 sentences.arrow_forwardMatch the following terms with the correct description Go phase A. During this phase, the cell divides into two identical cells. G, phase B. During this phase, the cell grows In size and synthesizes MRNA Gz phase C. This phase directly precedes mitosis. s phase D. This phase can be percelved as a moment in time in which the cell is nelther dividing nor preparing to divide. M phase E. DNA Is replicated during this phase.arrow_forward
- of my celle chose are wels smaller than normal. According to Model 1, what part(e) of the cell cycle is (ere) ou likely being affected? Some cancerus me 7. In Model 1, if the length of the arrow represents time, then for those cancerous cells, what hap pens to the time that is necessary for the cell cycle? What implication might this have for doctors who are treating cancer patients? Why? Living things must grow and develop. At times they suffer injuries or damage, or cells simply wear out. New cells must be formed for the organism to survive. What process must occur to make a new, properly- functioning cell? Model 1 - Mitosis as Part of the Cell Cycle Prophase Metaphase Anaphase Mitosis How do living things grow and repair themselves! Replicated chromosome (2 sister chromatids) 0000 * Centriole Spindle fibers Nuclear membrane Telophase 1. Refer to Model 1. List the four phases in the mitosis process. 2. Where is mitosis in the cell cycle? Before 3. What three phases of the cell cycle…arrow_forwardExplain why we can say that M-phase of the cell-cycle is triggered by a positive feedback loop. a) What would the consequences be if cohesins were working normally but condensins were not? and b) what stage of the cell cycle would this cause problems in? Why is it important for the centrosome to duplicate during G1-G2 (interphase) before M phase? The kinetochores serve as a link between the sister chromatids and the microtubules attached to the mitotic spindle. a) How are microtubules still able to exhibit dynamic instability after they are bound to the sister chromatids and b) why is this important to mitosis? As the name suggests, the Anaphase-promoting-complex (APC), promotes the 4th phase of mitosis by separating the sister chromatids so they can travel to separate poles of the cell, and prevents them from being re-zipped together. Describe how APC does these two things (Hint: one involves M-cyclin and the other involves…arrow_forwardResearchers determined the average amount of time that a particular eukaryotic cell spends in each phase of the cell cycle. The data collected by the researchers are represented in Figure 1 of the video. Based on Figure 1, what percent of the time required to complete a full cycle do the cells typically spend in interphase? A. Restate the question and record the right answer. B. Why is this the correct answer?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biology: The Dynamic Science (MindTap Course List)BiologyISBN:9781305389892Author:Peter J. Russell, Paul E. Hertz, Beverly McMillanPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
cell division of meiosis and mitosis; Author: Stated Clearly;https://www.youtube.com/watch?v=A-mFPZLLbHI;License: Standard youtube license