In the amino acid sequence of human insulin, each Asp, Glu, His, Lys and Arg has to be listed and whether the human insulin contain isoelectric point near acidic amino acid, neutral amino acid or basic amino acid has to be given.

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Chapter 27, Problem 27.38P

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Interpretation:

In the amino acid sequence of human insulin, each Asp, Glu, His, Lys and Arg has to be listed and whether the human insulin contain isoelectric point near acidic amino acid, neutral amino acid or basic amino acid has to be given.

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8. The following proteins represent a wide range of molecular weights and isoelectric points. Mr is the molecular weight of a single protein chain. • Protein 1: Mr 68,544; pl 6.11 (monomer) • Protein 2: Mr 29,041; pl 5.32 (dimer) • Protein 3: Mr 15,805; pl 5.7 (dimer) • Protein 4: Mr 12,165; pl 4.74 a. Which protein is the most acidic? Explain your answer. b. Which protein will migrate the slowest in an SDS-PAGE? Explain your answer. c. In what order will these proteins elute from a cation exchanger at pH 8? Explain your answer. d. In what order will these proteins salt out from a pH 7 solution by the dropwise addition of saturated ammonium sulfate? Explain your answer. 5 83°F Cloudy

Examine the amino acid sequence of human insulin (Figure 27.16) and list each Asp, Glu, His, Lys, and Arg in this molecule. Do you expect human insulin to have an isoelectric point nearer that of the acidic amino acids (pI 2.0–3.0), the neutral amino acids (pI 5.5–6.5) or the basic amino acids (pI 9.5–11.0)?

All amino acids have two ionizable functional groups: an α‑amino group (average pKa of 9.4) and an α‑carboxylic acid group (average pKa of 2.2). Aspartic acid has an ionizable side chain (R group) with a pKa of about 3.8. One of the possible ionization states of aspartic acid is shown in the image. At what pH would the structure be the predominant ionization state? Consider the ionization state of all three of the functional groups.

Answer 2

Question

Chapter 27, Problem 27.38P

Interpretation Introduction

Interpretation:

In the amino acid sequence of human insulin, each Asp, Glu, His, Lys and Arg has to be listed and whether the human insulin contain isoelectric point near acidic amino acid, neutral amino acid or basic amino acid has to be given.

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Answer 3

Question

Chapter 27, Problem 27.38P

Interpretation Introduction

Interpretation:

In the amino acid sequence of human insulin, each Asp, Glu, His, Lys and Arg has to be listed and whether the human insulin contain isoelectric point near acidic amino acid, neutral amino acid or basic amino acid has to be given.

Expert Solution & Answer

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Answer 4

Question

Chapter 27, Problem 27.38P

Interpretation Introduction

Interpretation:

In the amino acid sequence of human insulin, each Asp, Glu, His, Lys and Arg has to be listed and whether the human insulin contain isoelectric point near acidic amino acid, neutral amino acid or basic amino acid has to be given.

Expert Solution & Answer

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Answer 5

Chapter 27, Problem 27.38P

Interpretation Introduction

Interpretation:

In the amino acid sequence of human insulin, each Asp, Glu, His, Lys and Arg has to be listed and whether the human insulin contain isoelectric point near acidic amino acid, neutral amino acid or basic amino acid has to be given.

Answer 6

Chapter 27, Problem 27.38P

Interpretation Introduction

Interpretation:

In the amino acid sequence of human insulin, each Asp, Glu, His, Lys and Arg has to be listed and whether the human insulin contain isoelectric point near acidic amino acid, neutral amino acid or basic amino acid has to be given.

Answer 7

Chapter 27, Problem 27.38P

Interpretation Introduction

Interpretation:

In the amino acid sequence of human insulin, each Asp, Glu, His, Lys and Arg has to be listed and whether the human insulin contain isoelectric point near acidic amino acid, neutral amino acid or basic amino acid has to be given.

Answer 8

Expert Solution & Answer

Answer 9

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Answer 10

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Answer 11

Ch. 27.1 - Of the 20 protein-derived amino acids shown in...Ch. 27.2 - Prob. 27.2P Ch. 27.2 - Prob. 27.3P Ch. 27.3 - Draw a structural formula for Lys-Phe-Ala. Label...Ch. 27.4 - Which of these tripeptides are hydrolyzed by...Ch. 27.4 - Deduce the amino acid sequence of an undecapeptide...Ch. 27.6 - Prob. 27.7P Ch. 27 - What amino acid does each abbreviation stand for?...Ch. 27 - The configuration of the chiral center in -amino...Ch. 27 - Assign an R or S configuration to the chiral...

In the amino acid sequence of human insulin, each Asp, Glu, His, Lys and Arg has to be listed and whether the human insulin contain isoelectric point near acidic amino acid, neutral amino acid or basic amino acid has to be given.

Solution Summary: The author explains that the isoelectric point of human insulin can be calculated by using the amino acids Asp, Glu, His, Lys and Arg.

Concept explainers

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Interpretation:

In the amino acid sequence of human insulin, each Asp, Glu, His, Lys and Arg has to be listed and whether the human insulin contain isoelectric point near acidic amino acid, neutral amino acid or basic amino acid has to be given.

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Chapter 27 Solutions

In the amino acid sequence of human insulin, each Asp, Glu, His, Lys and Arg has to be listed and whether the human insulin contain isoelectric point near acidic amino acid, neutral amino acid or basic amino acid has to be given.

Solution Summary: The author explains that the isoelectric point of human insulin can be calculated by using the amino acids Asp, Glu, His, Lys and Arg.

Concept explainers

Videos

Interpretation: In the amino acid sequence of human insulin, each Asp, Glu, His, Lys and Arg has to be listed and whether the human insulin contain isoelectric point near acidic amino acid, neutral amino acid or basic amino acid has to be given.

Want to see the full answer?

Chapter 27 Solutions

Interpretation:

In the amino acid sequence of human insulin, each Asp, Glu, His, Lys and Arg has to be listed and whether the human insulin contain isoelectric point near acidic amino acid, neutral amino acid or basic amino acid has to be given.