EBK ORGANIC CHEMISTRY-PRINT COMPANION (
EBK ORGANIC CHEMISTRY-PRINT COMPANION (
4th Edition
ISBN: 9781119776741
Author: Klein
Publisher: WILEY CONS
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Chapter 25, Problem 56PP
Interpretation Introduction

Interpretation:

Preparation of valine by using Strecker synthesis needs to be shown.

Concept introduction:

Strecker synthesis is a process in which the aldehyde reacts with ammonium chloride and alkali cyanide to form α -aminonitrile.  The formed α -aminonitrile is undergoes hydrolysis to give the respective amino acids.  The general scheme can be shown as,

EBK ORGANIC CHEMISTRY-PRINT COMPANION (, Chapter 25, Problem 56PP

Steps involved in Strecker synthesis are,

  • Protonation of carbonyl
  • Nucleophilic attack of ammonia to form imine
  • Attack of cyanide to form α -aminonitrile
  • Hydrolysis to give α -aminoacid

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Chapter 25 Solutions

EBK ORGANIC CHEMISTRY-PRINT COMPANION (

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