Fundamentals of Biochemistry: Life at the Molecular Level
Fundamentals of Biochemistry: Life at the Molecular Level
5th Edition
ISBN: 9781118918401
Author: Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher: WILEY
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Chapter 24, Problem 36CQ
Summary Introduction

To calculate: The change in the linking number (L), writhing number (W), and twist upon B-DNA to Z-DNA transition.

Concept introduction: DNA molecules have different conformational changes based upon its state, which could be described by the topological characteristics of the DNA. Topological characteristics of a particular DNA consist of three important parameters. Those include, linking number, twist, and writhing. The twist number (T) is a total number of turns in the helix of the circular DNA and writhing (W) depicts the shape of the whole DNA molecule. The algebraic sum of both twist number and writhing gives the linking number (L).

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