Organic Chemistry (8th Edition)
Organic Chemistry (8th Edition)
8th Edition
ISBN: 9780134042282
Author: Paula Yurkanis Bruice
Publisher: PEARSON
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Chapter 24, Problem 33P
Interpretation Introduction

Interpretation:

The product obtained in the reduction reaction of α-ketoglutarate by a mutated form of isocitratedehydrogenase should be drawn.

Concept Introduction:

Glycolysis: It is pathway which describes conversion of one molecule of glucose into two molecules of pyruvate.  The series involves 10 reactions.

NAD+Molecule: It is the oxidized form of Nicotinamide adenine dinucleotide (NAD) which exists in all cells and needed for activation of enzymes.

NADHmolecule: It is coenzyme which gets oxidized on reducing another compound. The oxidized form of NADHisNAD+.

Citric acid cycle: The cycle in which acetyl group of each molecule of acetyl-CoA is converted into two molecules of CO2  It is a series of eight reactions.

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The rate-limiting step is a metabolic pathway is the slowest step which determines the overall rate of the other reactions in the pathway. In glycolysis, the rate limiting step is a phosphorylation reaction where phosphofructokinase (PFK-1) catalyzes the reaction fructose-6-bisphosphate -> fructose-1,6-bisphosphate, the same step in gluconeogenesis. Select one: The statement is FALSE. The statement is TRUE.
In some brain cancer cells, a mutated form of isocitrate dehydrogenase, instead of catalyzing the oxidation of the secondary alcohol of isocitrate, catalyzes the reduction of alpha-ketoglutarate. Draw the product of the reaction.
What is the function of the enzyme succinate dehydrogenase?

Chapter 24 Solutions

Organic Chemistry (8th Edition)

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