Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 23, Problem 23.9PS
Scrambled Eggs. Unfertilized starfish eggs can be induced to produce foreign proteins either by injecting them with mRNA encoding the protein of choice or by directly injecting them with purified molecules. What do you predict would happen in the following cases, and why?
(a) “Caged calcium,” a combination of calcium ions and a chelator, is injected into an egg. A flash of light is then used to induce the chelator to release its Ca2+ in a small region of the egg.
(b) mRNA for IP3 receptors that do not allow Ca2+ release is injected, and then the egg is fertilized.
(c) Fluo3, a molecule that fluoresces in response to elevated Ca2+ levels, is injected into normal eggs, which are then fertilized.
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The figure shows the number of cells that have clusters of IRE1 molecules after those cells are treated with various levels of thapsigargin (Tg), a chemical that can induce ER stress. IRE1 can form these clusters when ER stress is induced and this clustering can cause activation of RNAse activity in IRE1. In this experiment, normal IRE1 was used (IRE1α) that can bind to Sec61, along with a modified version of IRE1 that binds to Sec61 more weakly than normal IRE1 (wIRE1α), and another modified version that binds to Sec61 more strongly than normal IRE1 (sIRE1α). From this figure you can conclude that:
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IRE1 binding to Sec61 promotes the formation of IRE1 clumps
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co-translational translocation is a key process
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Chapter 23 Solutions
Becker's World of the Cell (9th Edition)
Ch. 23 - One effect of the hormone insulin is to cause...Ch. 23 - You are working on a new species of sea urchin...Ch. 23 - The Ca2+ concentration in unstimulated cells is...Ch. 23 - Prob. 23.3CCCh. 23 - Prob. 23.4CCCh. 23 - Prob. 23.5CCCh. 23 - Chemical Signals and Second Messengers. Fill in...Ch. 23 - QUANTITATIVE Pure agony. Agonists are drugs that...Ch. 23 - Heterotrimeric and Monomeric G Proteins. G...Ch. 23 - Calcium Chelators and Ionophores. In addition to...
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