Becker's World of the Cell (9th Edition)
Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 23, Problem 23.4PS

Calcium Chelators and Ionophores. In addition to calcium ionophores, another tool that has aided studies of the role of Ca2+ in triggering different cellular events is calcium chelators. Chelators are compounds such as EGTA and EDTA that bind very tightly to calcium ions, thereby reducing nearly to zero the free (or available) Ca2+ concentration outside of the cell. Using these tools, describe how you could demonstrate that a hormone exerts its effect by (1) causing Ca2+ to enter the cell through channels or (2) releasing Ca2+ from intracellular stores such as the ER.

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