Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 23, Problem 23.3CC
Summary Introduction
To determine: The result when two types of cells which have knocked out GTPase activating protein (GAP) is treated with a similar concentration of epidermal growth factor (EGF).
Introduction: Cells divides to fulfill the criteria for growth and development. The process which helps in the production or synthesis of new cells is called “cell cycle.” The use of epidermal growth factor (EGF) on the dividing cells results in the increase of cellular dividing capacity and hence, increases in the rate of cell division.
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Use the SGF-signaling pathway image as a reference, to answer the following questions. Use the data provided to EXPLAIN if the
cell will get to the response step or not. Keep in mind the purpose of this pathway is to cause skin cell division
Growth Factor (GF-signal) Activation of GF Receptor (RTK-receptor)
To cause Cell proliferation/cell division (Response)
Plasma membrane
Sos
Grb2
(Ras GEF)
(adapter)
Raf
МАРКK
Mek
МАРКK
Activation of target
genes that stimulate
proliferation
Erk
МАРК
You have a skin cell in a dish and have added Neural Growth Factor (NGF) to the cell media (the liquid the cell needs to live).
RAS is a signal transducer that acts as a switch for turning on cell division. Drag the descriptions below to their proper places on the
figure to show the sequence of events.
When growth factor
binds to the receptor,
the intracellular domain
activates RAS by
facilitating exchange of
GDP for GTP.
When no growth factor
is bound to the
extracellular receptor,
RAS is bound to GDP
and is inactive.
RAS activates the
first of three
sequential kinase
proteins termed the
MAP kinase cascade.
Cell proliferation
proceeds as the
machinery for cell
division is set in
motion.
The end result of the
MAP kinase cascade
is activation of a
transcription factor.
Receptor
1
Ras
GDP
2
4
5
Growth factor
Ras
GTP
If a cell expresses a dominant-negative tyrosine-kinase-linked receptor (RTK) that lacks the kinase domain, which of the following will
still happen in response to a growth factor that binds the RTK?
A Receptor cross-phosphorylation.
Activation of target proteins by Ras.
C) Receptor dimerization.
D) Binding of the growth factor to its receptor.
Interaction of Ras with the activated receptor.
B
Chapter 23 Solutions
Becker's World of the Cell (9th Edition)
Ch. 23 - One effect of the hormone insulin is to cause...Ch. 23 - You are working on a new species of sea urchin...Ch. 23 - The Ca2+ concentration in unstimulated cells is...Ch. 23 - Prob. 23.3CCCh. 23 - Prob. 23.4CCCh. 23 - Prob. 23.5CCCh. 23 - Chemical Signals and Second Messengers. Fill in...Ch. 23 - QUANTITATIVE Pure agony. Agonists are drugs that...Ch. 23 - Heterotrimeric and Monomeric G Proteins. G...Ch. 23 - Calcium Chelators and Ionophores. In addition to...
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