Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 2.3, Problem 14CC
Summary Introduction
To determine: The candidate molecule which proves to be a better potential drug if molecule A has a Kd of 4.9 and molecule B has a Kd of 0.3 for the receptor.
Introduction: Kd or the dissociation constant is a quantity which determines the degree around which the given molecule remains dissociated into ions in a solution. It is reciprocal of the equilibrium constant, which is a quantitative representation of the binding affinity of a protein to its ligand.
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The Graph below shows the binding curves of two proteins (A and B) for the same ligand (L). Use this Graph and determine the
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Given that the protein concentration is 0.25 μM, what is the association constant (KA) of the ligand-protein interaction? As this is a rough estimate, you do not need to report uncertainty on your result. The data pic is attached.
Chapter 2 Solutions
Human Physiology: An Integrated Approach (8th Edition)
Ch. 2.1 - List three major essential elements found in the...Ch. 2.1 - What is the general formula of a carbohydrate?Ch. 2.1 - Prob. 3CCCh. 2.1 - Prob. 4CCCh. 2.1 - Prob. 5CCCh. 2.1 - Prob. 6CCCh. 2.2 - Which dissolve more easily in water, polar...Ch. 2.2 - Prob. 8CCCh. 2.2 - Why does table salt (NaCl) dissolve in water?Ch. 2.2 - Prob. 10CC
Ch. 2.2 - pH is an expression of the concentration of what...Ch. 2.2 - Prob. 12CCCh. 2.3 - Prob. 13CCCh. 2.3 - Prob. 14CCCh. 2.3 - Match each chemical to its action(s).Ch. 2.3 - What happens to the rate of an enzymatic reaction...Ch. 2.3 - What happens to the rate of an enzymatic reaction...Ch. 2 - Prob. 1CRQCh. 2 - Prob. 2CRQCh. 2 - Prob. 3CRQCh. 2 - Prob. 4CRQCh. 2 - Name the element associated with each of these...Ch. 2 - Write the one- or two-letter symbol for each of...Ch. 2 - Prob. 7CRQCh. 2 - Prob. 8CRQCh. 2 - H+ is also called a proton. Why is it given that...Ch. 2 - Prob. 10CRQCh. 2 - Prob. 11CRQCh. 2 - Prob. 12CRQCh. 2 - Prob. 13CRQCh. 2 - Prob. 14CRQCh. 2 - Prob. 15CRQCh. 2 - What aspect of protein structure allows proteins...Ch. 2 - Prob. 17CRQCh. 2 - List the three components of a nucleotide.Ch. 2 - Compare the structure of DNA with that of RNA.Ch. 2 - Distinguish between purines and pyrimidines.Ch. 2 - Prob. 1RQCh. 2 - Prob. 2RQCh. 2 - Prob. 3RQCh. 2 - Prob. 4RQCh. 2 - Fill in the blanks with the correct bond type. In...Ch. 2 - Prob. 6RQCh. 2 - Prob. 7RQCh. 2 - Prob. 8RQCh. 2 - Prob. 9RQCh. 2 - Prob. 10RQCh. 2 - Prob. 11RQCh. 2 - A molecule that binds to another molecule is...Ch. 2 - Prob. 13RQCh. 2 - Prob. 14RQCh. 2 - Prob. 15RQCh. 2 - Prob. 16RQCh. 2 - A solution in which [H+] = 103 M is...Ch. 2 - Prob. 18RQCh. 2 - Prob. 19RQCh. 2 - Prob. 20RQCh. 2 - Prob. 21RQCh. 2 - Prob. 22RQCh. 2 - Prob. 23RQCh. 2 - Prob. 24RQCh. 2 - Prob. 25RQCh. 2 - The graph shown below represents the binding of...
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