Human Physiology: An Integrated Approach (8th Edition)
Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 2.3, Problem 14CC
Summary Introduction

To determine: The candidate molecule which proves to be a better potential drug if molecule A has a Kd of 4.9 and molecule B has a Kd of 0.3 for the receptor.

Introduction: Kd or the dissociation constant is a quantity which determines the degree around which the given molecule remains dissociated into ions in a solution. It is reciprocal of the equilibrium constant, which is a quantitative representation of the binding affinity of a protein to its ligand.

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The Graph below shows the binding curves of two proteins (A and B) for the same ligand (L). Use this Graph and determine the dissociation constant, K, for both proteins. Which protein (A or B) has a greater affinity for ligand L? Which of the two proteins would be more easily inhibited by an antagonist? 1.0 Y 0.5 2 A 4 6 B 8 [L] (μM) 10 12 14 16
The dissociation equilibrium constant (Kd) is:_____ (select all that apply) Group of answer choices: Is a measure of ligand efficacy Typically equivalent to 1- Ka The concentration of ligand that gives maximal receptor occupancy The concentration of ligand that gives half-maximal receptor occupancy Measured in 1/M or M-1 Typically measured in mol/L or M A measure of the strength of a ligand - receptor binding reaction
The binding of a ligand quenches the fluorescence of a protein. The following data were acquired: Given that the protein concentration is 0.25 μM, what is the association constant (KA) of the ligand-protein interaction? As this is a rough estimate, you do not need to report uncertainty on your result. The data pic is attached.

Chapter 2 Solutions

Human Physiology: An Integrated Approach (8th Edition)

Ch. 2.2 - pH is an expression of the concentration of what...Ch. 2.2 - Prob. 12CCCh. 2.3 - Prob. 13CCCh. 2.3 - Prob. 14CCCh. 2.3 - Match each chemical to its action(s).Ch. 2.3 - What happens to the rate of an enzymatic reaction...Ch. 2.3 - What happens to the rate of an enzymatic reaction...Ch. 2 - Prob. 1CRQCh. 2 - Prob. 2CRQCh. 2 - Prob. 3CRQCh. 2 - Prob. 4CRQCh. 2 - Name the element associated with each of these...Ch. 2 - Write the one- or two-letter symbol for each of...Ch. 2 - Prob. 7CRQCh. 2 - Prob. 8CRQCh. 2 - H+ is also called a proton. Why is it given that...Ch. 2 - Prob. 10CRQCh. 2 - Prob. 11CRQCh. 2 - Prob. 12CRQCh. 2 - Prob. 13CRQCh. 2 - Prob. 14CRQCh. 2 - Prob. 15CRQCh. 2 - What aspect of protein structure allows proteins...Ch. 2 - Prob. 17CRQCh. 2 - List the three components of a nucleotide.Ch. 2 - Compare the structure of DNA with that of RNA.Ch. 2 - Distinguish between purines and pyrimidines.Ch. 2 - Prob. 1RQCh. 2 - Prob. 2RQCh. 2 - Prob. 3RQCh. 2 - Prob. 4RQCh. 2 - Fill in the blanks with the correct bond type. In...Ch. 2 - Prob. 6RQCh. 2 - Prob. 7RQCh. 2 - Prob. 8RQCh. 2 - Prob. 9RQCh. 2 - Prob. 10RQCh. 2 - Prob. 11RQCh. 2 - A molecule that binds to another molecule is...Ch. 2 - Prob. 13RQCh. 2 - Prob. 14RQCh. 2 - Prob. 15RQCh. 2 - Prob. 16RQCh. 2 - A solution in which [H+] = 103 M is...Ch. 2 - Prob. 18RQCh. 2 - Prob. 19RQCh. 2 - Prob. 20RQCh. 2 - Prob. 21RQCh. 2 - Prob. 22RQCh. 2 - Prob. 23RQCh. 2 - Prob. 24RQCh. 2 - Prob. 25RQCh. 2 - The graph shown below represents the binding of...
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