The mechanism for conversion of carbon dioxide to bicarbonate ion in presence of carbonic anhydrase has to be proposed. Concept introduction: Enzyme is a protein that is a biological catalyst. The reactant in a reaction catalyzed by the enzyme is called substrate. In the enzyme, a pocket like cleft is present called active site where it binds the substrate. Some amino acid chains in the enzyme act as base, acid and nucleophilic catalyst. Many of the enzymes contain metal ions at the active site which acts as catalyst. Acid Catalyst helps in increasing the rate of a particular reaction by the donation of a proton to substrate. Base Catalyst helps in increasing the rate of a particular reaction by the removal of a proton to substrate. Nucleophilic catalysis helps in increasing the rate of a particular reaction by the formation of a covalent bond with substrate Metalloenzyme: An enzyme which has a tightly bound Z n 2 + metal ion

Question

Oxaloacetate is an inhibitor of succinate dehydrogenase because it is structurally very similar to succinate as shown below. Also, its binding to the enzyme does not involve any covalent bond formation. What type of inhibitor is oxaloacetate? COO | CH₂ 1 CH₂ 1 COO Succinate COO | CH₂ C=O COO Oxaloacetate O a noncompetitive inhibitor both a noncompetitive and an irreversible inhibitor O an irreversible inhibitor O a competitive inhibitor

Answer 1

Question

Chapter 22, Problem 39P

Interpretation Introduction

Interpretation: The mechanism for conversion of carbon dioxide to bicarbonate ion in presence of carbonic anhydrase has to be proposed.

Concept introduction:

Enzyme is a protein that is a biological catalyst. The reactant in a reaction catalyzed by the enzyme is called substrate. In the enzyme, a pocket like cleft is present called active site where it binds the substrate.

Some amino acid chains in the enzyme act as base, acid and nucleophilic catalyst. Many of the enzymes contain metal ions at the active site which acts as catalyst.

Acid Catalyst helps in increasing the rate of a particular reaction by the donation of a proton to substrate.

Base Catalyst helps in increasing the rate of a particular reaction by the removal of a proton to substrate.

Nucleophilic catalysis helps in increasing the rate of a particular reaction by the formation of a covalent bond with substrate

Metalloenzyme: An enzyme which has a tightly bound Zn2+ metal ion

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