WHAT IS LIFE? A GUIDE TO BIO 3E+LAUNCHPA
3rd Edition
ISBN: 9781319103316
Author: PHELAN
Publisher: Macmillan Higher Education
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Chapter 21, Problem 11MC
Summary Introduction
Introduction:
The blood carries CO2 and O2 from and to the tissues in the body. Hemoglobin is the protein responsible for the transport of oxygen.
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How does the concentration of 2,3 BPG affect hemoglobin's P50 for oxygen? select the correct answer
A) BPG binds to the N-terminus of Hemoglobin's alpha 2 subunit and increase hemoglobin's P50 for oxygen.
B) BPG binds to the heme blocking oxygen's ability to bind and lowering hemoglobin's P 50.
C) As the BPG increases hemoglobin's P50 for oxygen increase.
D) As the BPG increases hemoglobin's P50 for oxygen decreases.
E) BPG does not affect hemoglobin's P50 for oxygen
Which of the following concerning hemoglobin is true?
a) BPG decreases at high altitudes and causes more O2 offloading in tissues
b) As pH increases, [CO2] increases in tissues, causing more O2 release in tissue
c) The R state is stabilized by CO2 binding, whereas the T state is stabilized by O2 binding
d) About 38% of oxygen dissociates from hemoglobin in tissues
e) Hemoglobin has a higher affinity for oxygen than carbon monoxide
My guess is D.
Which of the following concerning hemoglobin is true?
a) BPG decreases at high altitudes and causes more O2 offloading in tissues
b) As pH increases, [CO2] increases in tissues, causing more O2 release in tissue
c) The R state is stabilized by CO2 binding, whereas the T state is stabilized by O2 binding
d) About 38% of oxygen dissociates from hemoglobin in tissues
e) Hemoglobin has a higher affinity for oxygen than carbon monoxide
My guess is D.
What following statement is TRUE concerning motifs and domains?
a) Both motifs and domains are independently stable.
b) Domains undergo dynamic individual changes that affect the entire protein
c) B-a-ß loops, B barrels, and helix-turn-helix structure are types of domains
d) Motifs and domains are part of secondary structural elements
e) Ab initio computations predict motif folds accurately a majority of the time
My guess is B.
Which of the following is TRUE under the following conditions: an enzyme displaying Michaelis-Menten kinetics…
Chapter 21 Solutions
WHAT IS LIFE? A GUIDE TO BIO 3E+LAUNCHPA
Ch. 21 - Prob. 1SACh. 21 - Prob. 2SACh. 21 - Prob. 3SACh. 21 - Prob. 4SACh. 21 - Prob. 5SACh. 21 - Prob. 6SACh. 21 - Prob. 7SACh. 21 - Prob. 8SACh. 21 - Prob. 9SACh. 21 - Prob. 10SA
Ch. 21 - Prob. 11SACh. 21 - Prob. 12SACh. 21 - Prob. 13SACh. 21 - Prob. 14SACh. 21 - Prob. 15SACh. 21 - Prob. 16SACh. 21 - Prob. 17SACh. 21 - Prob. 18SACh. 21 - Prob. 1MCCh. 21 - Prob. 2MCCh. 21 - Prob. 3MCCh. 21 - Prob. 4MCCh. 21 - Prob. 5MCCh. 21 - Prob. 6MCCh. 21 - Prob. 7MCCh. 21 - Prob. 8MCCh. 21 - Prob. 9MCCh. 21 - Prob. 10MCCh. 21 - Prob. 11MCCh. 21 - Prob. 12MCCh. 21 - Prob. 13MCCh. 21 - Prob. 14MCCh. 21 - Prob. 15MCCh. 21 - Prob. 16MCCh. 21 - Prob. 17MCCh. 21 - Prob. 18MC
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- a) How much more O2 can be transported by the blood when erythrocytesleave the lungs? Consider that a normal adult has a concentration of 15 g hemoglobin/100 mL of bloodand that the hemoglobin is 98% saturated with O2 at the usual pO2 of 100 torr in the lung at sea level. b) On the basis of the graph, explain how myoglobin facilitates the diffusion of O2 through muscle cells. Would myoglobin be effective as an O2-transport protein in cells of other tissues? Explain.arrow_forwardWhich of the links below are true? a) The cysteine moieties in the beta globulin - nitric oxide transport b) The globe component in hemoglobin - carbon dioxide transport c) The home group in the hemoglobin - oxygen transport d) Carbonic anhydrase - carbon dioxide transportarrow_forwardWhy does Fe2+ not fit perfectly into the center hemoglobin's heme pocket, while Fe3+ does ift perfectly into center hemoglobin's heme pocket? A) Fe2+ has a larger effective nuclear charge than Fe3+ . B) Fe2+ is to reactive to stably fit into hemoglobin's heme pocket. C) Fe2+ had a wrinkled shirt D) Fe2+ is repelled by the heme's coordinating nitrogens E) Fe3+ is denser and has a smaller ionic radius than Fe2+arrow_forward
- Oxygen has an allosteric interaction with hemoglobin. What are the results of this interaction as oxygen a) binds to and b) is released from hemoglobin?arrow_forwardWhy is the binding of oxygen to hemoglobin cooperative while the binding of oxygen to myoglobin is not? A) Myoglobin has more x-helix than hemoglobin B) Hemoglobin has more iron (Fe) atoms C) Hemoglobin has more than one subunit D) Myoglobin is affected by changes in pHarrow_forwardCarbon monoxide (CO) is toxic to humans because it: A) is rapidly converted to toxic CO2. B) binds to the globin portion of hemoglobin and prevents the binding of O2. C) binds to myoglobin and causes it to denature. D) binds to the heme portion of hemoglobin and causes heme to unbind from hemoglobin. E) binds to the Fe in hemoglobin and prevents the binding of O2.arrow_forward
- 1. a) True or False - A mutation in the beta globin gene that causes conversion of His146 to Glutamate would decrease Hemoglobin’s O2 binding affinity. b) True or False - A mutation in the beta globin gene that causes conversion of His146 to Glutamate would eliminate Hemoglobin’s positive cooperativity.arrow_forwardplease helparrow_forwardWhich one of the following statements concerning Hb (hemoglobin) A1c is CORRECT? Question 4 options: a) HbA1c contains glucose molecules b) The concentration of HbA1c in the red blood cells (RBCs) decreases as RBCs age in the circulation c) Insulin injection can decrease the amount of HbA1c in the blood d) Weight is correlated with HbA1c concentrationarrow_forward
- Consider this figure, which shows oxygen binding to hemoglobin under various conditions 1.0 В A 0.5- pO2 a) If B is normal hemoglobin what could lead to curve hemoglobin A. b) If B is normal hemoglobin what could lead to curve hemoglobin C. c) Which curve shows the hemoglobin with the highest O2 affinity? d) Which curve shows the hemoglobin with the lowest P50? (Saturation)arrow_forward21. Which of the following compounds in erythrocytes is decreased in patients with a deficiency of glucose-6-phosphate dehydrogenase? A) Deoxyribose B) Ribose C) NADH D) NADPH E) NADP+arrow_forwardAt high altitude, red blood cells ____ production of BPG, which causes a/an ____ in Hb's O2 binding affinity. a) Increase; increase b) Decrease; increase c) Decrease; decrease d) Increase; decreasearrow_forward
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