a) How much more O2 can be transported by the blood when erythrocytesleave the lungs? Consider that a normal adult has a concentration of 15 g hemoglobin/100 mL of bloodand that the hemoglobin is 98% saturated with O2 at the usual pO2 of 100 torr in the lung at sea level.b) On the basis of the graph, explain how myoglobin facilitates the diffusion of O2 through muscle cells. Would myoglobin be effective as an O2-transport protein in cells of other tissues? Explain. 1. (a) The solubility of the dioxygen (O₂) molecule in blood at 37° C and ionic strength equivalentto 0.15 M NaCl is ~10-4 M. How much more O₂ can be transported by the blood when erythrocytesleave the lungs? Consider that a normal adult has a concentration of 15 g hemoglobin/100 mL of bloodand that the hemoglobin is 98% saturated with O2 at the usual pO2 of 100 torr in the lung at sea level.1.00(b)The diagram to the right contrasts the oxygenbinding curve of normal human hemoglobin (HbA) to thatof myoglobin, a single polypeptide hemeprotein that servesas an oxygen storage protein in cardiac and skeletal mus-cle. The partial pressure of O2 (pO2) is given along the hor-izontal axis in units of torr (mm Hg) and is directly propor-tional to the concentration of dissolved oxygen in the solu-tion. The variable Yoz represents the fraction of heme sites Yooccupied by ligand. It is seen that the O2 dissociation curvefor myoglobin is hyperbolic in shape while that of hemoglo-bin is sigmoidal. The two proteins exhibit high sequenceidentity and possess the same prosthetic group, iron-pro-tophyrin IX. The dashed curve is of a hypothetical mutantform of Hb with a p50 identical to that of normal HbA.In active muscle tissue the pO2 is approximately 10 torr atthe cell surface but only 1 torr in mitochondria. Active mus-cle tissue consumes 0₂ much faster than other tissues. Formyoglobin the pO2 at 50% saturation is 2.8 torr. On the ba-sis of the graph, explain how myoglobin facilitates the diffu-sion of O2 through muscle cells. Would myoglobin be effec-tive as an O2-transport protein in cells of other tissues? Ex-plain.0.800.600.400.200.0MyoglobinVenous pressure2040Hemoglobinin whole bloodArterial pressure60p0₂ (tor)Comparison of oxygen dissociationcurves for human hemoglobin (HbA)and myoglobin. The p50 of normal he-moglobin is 26 torr. That of myoglobinis 2.8 torr.80 100 120

Myoglobin and Hemoglobin are both oxygen binding protein. Myoglobin is made up of a single…

a) How much more O2 can be transported by the blood when erythrocytes leave the lungs? Consider that a normal adult has a concentration of 15 g hemoglobin/100 mL of blood and that the hemoglobin is 98% saturated with O2 at the usual pO2 of 100 torr in the lung at sea level. b) On the basis of the graph, explain how myoglobin facilitates the diffusion of O2 through muscle cells. Would myoglobin be effective as an O2-transport protein in cells of other tissues? Explain

a) How much more O2 can be transported by the blood when erythrocytes leave the lungs? Consider that a normal adult has a concentration of 15 g hemoglobin/100 mL of blood and that the hemoglobin is 98% saturated with O2 at the usual pO2 of 100 torr in the lung at sea level. b) On the basis of the graph, explain how myoglobin facilitates the diffusion of O2 through muscle cells. Would myoglobin be effective as an O2-transport protein in cells of other tissues? Explain

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter11: The Blood

Section: Chapter Questions

Problem 1SQE

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