At high altitude, red blood cells ____ production of BPG, which causes a/an ____ in Hb's O2 binding affinity. a) Increase; increase b) Decrease; increase c) Decrease; decrease d) Increase; decrease
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At high altitude, red blood cells ____ production of BPG, which causes a/an ____ in Hb's O2 binding affinity.
a) Increase; increase
b) Decrease; increase
c) Decrease; decrease
d) Increase; decrease
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- 1. a) True or False - A mutation in the beta globin gene that causes conversion of His146 to Glutamate would decrease Hemoglobin’s O2 binding affinity. b) True or False - A mutation in the beta globin gene that causes conversion of His146 to Glutamate would eliminate Hemoglobin’s positive cooperativity.Which one of the following statements concerning Hb (hemoglobin) A1c is CORRECT? Question 4 options: a) HbA1c contains glucose molecules b) The concentration of HbA1c in the red blood cells (RBCs) decreases as RBCs age in the circulation c) Insulin injection can decrease the amount of HbA1c in the blood d) Weight is correlated with HbA1c concentrationThe sigmoidal, cooperative binding curve commonly observed for hemoglobin is a result of: a) competition between CO2 and O2 for heme binding. B) competition between heme and distal His for O2 binding c) competition between BPG and CO2 for binding at the central cavity site d) T to R transition Hemoglobin has a tendency to release its oxygen to the tissues because: a) in this region pH is high and O2 concentrations are low b) in this region both pH and O2 concentrations are low c) in this region both pH and O2 concentrations are high d) there is much BPG in this region Which statement about fetal hemoglobin is not true? A) fetal hemoglobin has gamma chains instead of beta chains b) fetal hemoglobin binds BPG less strongly than maternal hemoglobin c) fetal hemoglobin binds oxygen less strongly than maternal hemoglobin d) fetal hemoglobin binds oxygen more strongly than maternal hemoglobin Which process is most responsible for the sickling of cells seen in sickle…
- 3) which of the following would increase the relase of erythropoietin by the kidneys? A) all of these answers would cause an increase in erythropoietin release s B) decrease in red blood cells only C) decreased oxygen availability only D) hypoxia due to a decrease in red blood cells only F) increased tissue demand for oxygen onlyWhich process is most responsible for the sickling of cells seen in sickle cell disease? A) aggregation of the oxygenated R form of hemoglobin-S to form insoluble fibers b) aggregation of the deoxygenated T form of hemoglobin-S to form insoluble fibers c) Hemoglobin-S does not contain heme d) Hemoglobin-S contains a mutant form of heme which will not bind oxygen A person with sickle-cell trait is very unlikely to catch which disease? A) malaria b) colon cancer c) avian flu d) whooping cough27) All of the following laboratory values are consistent with an intravascular hemolytic anemia EXCEPT() A) increased haptoglobin B) Increased lactate dehydrogenase(LDH) C) Increased reticulocyte count D) Increased unconjugated bilirubin E) Increased urine hemosiderin
- Please help me with these questions. more than one solution may be correct for each one.1) Which statements regarding Erythrocruorin are correct? A) It usually contains 144 subunits but can have as many as 200 B) A low pH will signal hemoglobin to unload its oxygen C) A high pH will cause it to have a higher oxygen binding affinity D) It was a low oxygen binding affinity E) It is found in the blood cells of annelids 2) if you find yourself dehydrated and without water, you should Question 11 options: A) think about drinking someone else's pee B) NEVER, EVER drink your urine C) maybe contemplate sipping on your urine D) consider drinking your pee E) not drink your pee 3) Which of the following forces act on the filtrate when it is in the Bowman's space? A) colloid osmotic pressure B) pressure to perform C) glomerular capillary pressure D) podocyte pressure E) capsular pressureThe binding of 2,3-bisphosphoglycerate is lowest with: OA) Adult hemoglobin OB) Fetal hemoglobin OC) Sickle cell hemoglobin OD) It is the same for all threeWhich of the following is a sensitive indicator of early inon deficiency(). A) serum iron B) Transferrin saturation C) serum ferritin D) Erythrocyte free protoporphyrin E) Bone marrow can be stained with iron
- A) Why is it a problem that distilled water was used, instead of the saline drip? B) What happened to the patient's red blood cells after the IV with distilled water was used? C) What connection does this have to the patient's O2 levels? (Hint: think about why red blood cells are important) D) Why is a saline drip of 0.9% concentration normally used? E)What type of solution is this concentration, compared to the red blood cells? F) If this was really you, what would your next step be? How could you save this patient? G) On a practical note, can you drink too much water?A child is brought to the clinic due to repeated episodes of ear and lung infections. Investigations and history have revealed a deficiency of enzyme responsible for respiratory burst in the neutrophils .which of the following enzyme is deficient ? a) catalase b)NADPH oxidase c) superoxide dismutase d) myeloperoxidase.Why does Fe2+ not fit perfectly into the center hemoglobin's heme pocket, while Fe3+ does ift perfectly into center hemoglobin's heme pocket? A) Fe2+ has a larger effective nuclear charge than Fe3+ . B) Fe2+ is to reactive to stably fit into hemoglobin's heme pocket. C) Fe2+ had a wrinkled shirt D) Fe2+ is repelled by the heme's coordinating nitrogens E) Fe3+ is denser and has a smaller ionic radius than Fe2+