Organic Chemistry
Organic Chemistry
9th Edition
ISBN: 9781305080485
Author: John E. McMurry
Publisher: Cengage Learning
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Chapter 20.SE, Problem 41AP
Interpretation Introduction

Interpretation:

The pKa of uric acid is 5.61. The percent dissociation of uric acid in urine at a pH=6.0 is to be calculated. Why uric acid is acidic even though it does not have a COOH group is to be explained.

Concept introduction:

The Henderson-Hasselbalch equation is

Organic Chemistry, Chapter 20.SE, Problem 41AP

where, [A-] is the concentration of the dissociated uric acid and [HA] is the concentration of the undissociated uric acid.

A compound will be acidic and donate a proton, if the conjugate base obtained is stabilized by resonance.

To calculate:

The percent dissociation of uric acid in urine at a pH=6.0 if its pKa is 5.61 and to explain why uric acid is acidic even though it does not have a COOH group.

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Chapter 20 Solutions

Organic Chemistry

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