8th Edition

ISBN: 9781305268920

Author: Bernard Rosner

Publisher: Cengage Learning

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Chapter 2, Problem 33P

Activated-protein-C (APC) resistance is a serum marker that has been associated with thrombosis (the formation of blood clots often leading to heart attacks) among adults. A study assessed this risk factor among adolescents. To assess the reproducibility of the assay, a split-sample technique was used in which a blood sample was provided by 10 people; each sample was split into two aliquots (sub-samples), and each aliquot was assessed separately. Table 2.19 gives the results.

Table 2.19 APC resistance split-samples data

Chapter 2, Problem 33P, Activated-protein-C (APC) resistance is a serum marker that has been associated with thrombosis (the

To assess the variability of the assay, the investigators need to compute the coefficient of variation. Compute the coefficient of variation (CV) for each subject by obtaining the mean and standard deviation over the 2 replicates for each subject.

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Chapter 2, Problem 32P

Chapter 2, Problem 34P

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Chapter 2 Solutions

Fundamentals of Biostatistics

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Solution Summary: The author explains how to obtain the coefficient of variation for each subject by obtaining the mean and standard deviation over the 2 replicates.

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