Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 2, Problem 16RQ
Summary Introduction
To review:
Definition of the following terminologies:
(a) Intermembrane space
(b) Mitochondrial matrix
(c) Peroxisome
(d) Peroxin
Introduction:
Oxidative phosphorylation is one of the major roles of mitochondrial intermembrane space. During electron transport, protons move from the mitochondrial matrix to the intermembrane space.
There are proteins in the cytoplasm thatcontain PTS (peroxisomal targeting signals), which are recognized by peroxins.
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Question 1.
Enzymes, proteins and deoxyribonucleic acid (DNA) are important biological
macromolecules. Enzymes are not only speed up the reaction, but also are necessary for DNA
reproduction.
c) Describe an example of biomedical application that utilizes a protein folding technique.
d) Describe the effect of pH on the oxygen binding affinity of hemoglobin.
A metabolic pathway that functions in both anabolic andcatabolic processes is called an _____________________pathway.
__________ and_______________ are two granular organelles (enzyme complexes) that, respectively, synthesize and degrade proteins.
Chapter 2 Solutions
Biochemistry: The Molecular Basis of Life
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- Three proteins that facilitate the movement of phospholipidmolecules across a membrane are flippase, floppase, and_________________________.arrow_forwardThe molecule necessary fpr carbon to enter the Krebs cycle is _______________________.arrow_forwardQuestion 4. Diabetes mellitus possesses a serious health challenge worldwide and there has been an increased awareness for self-monitoring and point of care testing. The development of self- monitoring of blood glucose (SMBG) is probably the most important advance in controlling diabetes since the discovery of insulin. a) Dextrostix, the first glucose meter was invented by Ernie Adams. Briefly discuss. b) There are three principles of enzymatic reactions, utilized by current glucose meters. Compare and briefly discuss these three principles.arrow_forward
- Question 3.arrow_forwardThe synthesis of enzymes in response to changing metabolicneeds is referred to as _____________________.arrow_forwardQuestion 1. Enzymes, proteins and deoxyribonucleic acid (DNA) are important biological macromolecules. Enzymes are not only speed up the reaction, but also are necessary for DNA reproduction. e) Michaelis - Menten Kinetics model explains how reaction rates are depending on the concentration of enzyme and substrate. i. What is meant by the saturation of enzyme? ii. A decrement in enzyme activity is known as enzyme inhibition. Based on normal enzyme activity, explain the enzyme kinetics for competitive inhibition and noncompetitive inhibition, as shown in Figure 1. Normal enzyme Competitive inhibitor Noncompetitive inhibitor Substrate concentration Figure 1: Enzyme inhibition f) What is the importance of cofactor in the enzyme activity? Give an example of a disease that is related with cofactors. Rate of reactionarrow_forward
- The cell membrane contains certain pores in it. This allows only a few substances to pass through the cell membrane. This property is called _________________.arrow_forward_____________ are genetic diseases associated with defects in glycoconjugate synthesis reactions.arrow_forwardThe Multiprotein Complexes of the Electron Transport Chain Assemble into ___________.arrow_forward
- _____________ are molecules used in enzyme studies that resemble the structure of a substrate’s transition state.arrow_forwardQuestion 4.3 Now it's your turn to design and experiment. Your Aunt Kayla and Uncle Jerome, want to be home-brewers. When they find out that you have been studying yeast metabolism and the scientific method, they request your help in the study- design portion. Uncle Jerome likes beer that is very carbonated; whereas Aunt Kayla likes beer that is only mildly carbonated. They each want to make their own batch of beer. Using the information learned from this data, write instructions for each person in terms of which carbohydrate source to use and how long to allow the incubation to occur.arrow_forwardQuestion 13 Describe the four complexes of the electron transport chain. What are the carriers used to move electrons between complexes.arrow_forward
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