The text states that a side effect of 5-fluorouracil therapy is its incorporation into RNA. Show pathways by which 5-fluorouracil could be converted both to FdUMP and to an immediate RNA precursor. Concept Introduction: 5-FU is converted into 5-fluorouridine triphosphate (FUTP). FUTP incorporates into RNA in place of uridylic acid. It alters aminoacylation of tRNA causing RNA miscoding and inhibits protein synthesis. 5-FU is metabolized to 5-fluorodeoxyuridine monophosphate (FdUMP). FdUMP is a potent inhibitor of thymidylate synthetase, a key enzyme in the biosynthesis of DNA.

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Answer 1

Question

Chapter 19, Problem 7P

Interpretation Introduction

Interpretation:

The text states that a side effect of 5-fluorouracil therapy is its incorporation into RNA. Show pathways by which 5-fluorouracil could be converted both to FdUMP and to an immediate RNA precursor.

Concept Introduction:

5-FU is converted into 5-fluorouridine triphosphate (FUTP). FUTP incorporates into RNA in place of uridylic acid. It alters aminoacylation of tRNA causing RNA miscoding and inhibits protein synthesis.

5-FU is metabolized to 5-fluorodeoxyuridine monophosphate (FdUMP). FdUMP is a potent inhibitor of thymidylate synthetase, a key enzyme in the biosynthesis of DNA.

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Answer 2

Question

Chapter 19, Problem 7P

Interpretation Introduction

Interpretation:

The text states that a side effect of 5-fluorouracil therapy is its incorporation into RNA. Show pathways by which 5-fluorouracil could be converted both to FdUMP and to an immediate RNA precursor.

Concept Introduction:

5-FU is converted into 5-fluorouridine triphosphate (FUTP). FUTP incorporates into RNA in place of uridylic acid. It alters aminoacylation of tRNA causing RNA miscoding and inhibits protein synthesis.

5-FU is metabolized to 5-fluorodeoxyuridine monophosphate (FdUMP). FdUMP is a potent inhibitor of thymidylate synthetase, a key enzyme in the biosynthesis of DNA.

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Answer 3

Question

Chapter 19, Problem 7P

Interpretation Introduction

Interpretation:

The text states that a side effect of 5-fluorouracil therapy is its incorporation into RNA. Show pathways by which 5-fluorouracil could be converted both to FdUMP and to an immediate RNA precursor.

Concept Introduction:

5-FU is converted into 5-fluorouridine triphosphate (FUTP). FUTP incorporates into RNA in place of uridylic acid. It alters aminoacylation of tRNA causing RNA miscoding and inhibits protein synthesis.

5-FU is metabolized to 5-fluorodeoxyuridine monophosphate (FdUMP). FdUMP is a potent inhibitor of thymidylate synthetase, a key enzyme in the biosynthesis of DNA.

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Answer 4

Question

Chapter 19, Problem 7P

Interpretation Introduction

Interpretation:

The text states that a side effect of 5-fluorouracil therapy is its incorporation into RNA. Show pathways by which 5-fluorouracil could be converted both to FdUMP and to an immediate RNA precursor.

Concept Introduction:

5-FU is converted into 5-fluorouridine triphosphate (FUTP). FUTP incorporates into RNA in place of uridylic acid. It alters aminoacylation of tRNA causing RNA miscoding and inhibits protein synthesis.

5-FU is metabolized to 5-fluorodeoxyuridine monophosphate (FdUMP). FdUMP is a potent inhibitor of thymidylate synthetase, a key enzyme in the biosynthesis of DNA.

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Answer 5

Chapter 19, Problem 7P

Interpretation Introduction

Interpretation:

The text states that a side effect of 5-fluorouracil therapy is its incorporation into RNA. Show pathways by which 5-fluorouracil could be converted both to FdUMP and to an immediate RNA precursor.

Concept Introduction:

5-FU is converted into 5-fluorouridine triphosphate (FUTP). FUTP incorporates into RNA in place of uridylic acid. It alters aminoacylation of tRNA causing RNA miscoding and inhibits protein synthesis.

5-FU is metabolized to 5-fluorodeoxyuridine monophosphate (FdUMP). FdUMP is a potent inhibitor of thymidylate synthetase, a key enzyme in the biosynthesis of DNA.

Answer 6

Chapter 19, Problem 7P

Interpretation Introduction

Interpretation:

The text states that a side effect of 5-fluorouracil therapy is its incorporation into RNA. Show pathways by which 5-fluorouracil could be converted both to FdUMP and to an immediate RNA precursor.

Concept Introduction:

5-FU is converted into 5-fluorouridine triphosphate (FUTP). FUTP incorporates into RNA in place of uridylic acid. It alters aminoacylation of tRNA causing RNA miscoding and inhibits protein synthesis.

5-FU is metabolized to 5-fluorodeoxyuridine monophosphate (FdUMP). FdUMP is a potent inhibitor of thymidylate synthetase, a key enzyme in the biosynthesis of DNA.

Answer 7

Chapter 19, Problem 7P

Interpretation Introduction

Interpretation:

The text states that a side effect of 5-fluorouracil therapy is its incorporation into RNA. Show pathways by which 5-fluorouracil could be converted both to FdUMP and to an immediate RNA precursor.

Concept Introduction:

5-FU is converted into 5-fluorouridine triphosphate (FUTP). FUTP incorporates into RNA in place of uridylic acid. It alters aminoacylation of tRNA causing RNA miscoding and inhibits protein synthesis.

5-FU is metabolized to 5-fluorodeoxyuridine monophosphate (FdUMP). FdUMP is a potent inhibitor of thymidylate synthetase, a key enzyme in the biosynthesis of DNA.

Answer 8

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Answer 9

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Answer 10

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Answer 11

Ch. 19 - Prob. 1P Ch. 19 - Prob. 2P Ch. 19 - Predict the effects of the following compounds on...Ch. 19 - Prob. 4P Ch. 19 - Prob. 5P Ch. 19 - Prob. 6P Ch. 19 - Prob. 7P Ch. 19 - A classic way to isolate thymidylate...Ch. 19 - Prob. 9P Ch. 19 - Prob. 10P

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