Biochemistry: Concepts and Connections (2nd Edition)
Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 19, Problem 24P
Interpretation Introduction

Interpretation:

Mechanism of blocking the synthesis of DNA by thymidine should be identified.

Concept introduction:

The replication of DNA take place at S phase of cell cycle where the DNA get replicated. The conversion of nucleoside takes place to nucleoside triphosphate with in the cell where in presence of less oxygen it transforms into deoxygenated form. The accumulation this deoxygenated moiety leads to blocking the synthesis of DNA in cell.

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