Biochemistry
6th Edition
ISBN: 9781337359573
Author: Reginald H. Garrett; Charles M. Grisham
Publisher: Cengage Learning US
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Textbook Question
Chapter 19, Problem 22P
- Study Figure 19.18 and decide which of the following statements is false.
- Pyruvate dehydrogenase is inhibited by· NIADH.
- Pyruvate dehydrogenase is inhibited by AΤΡ.
- Citrate synthase is inhibited by NADH.
- Succinyl-CoA activates citrate synthase.
- Acetyl-CoA activates pyruvate carboxylase.
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Chapter 19 Solutions
Biochemistry
Ch. 19 - Radiolabeling with 14C-Glutamate Describe the...Ch. 19 - Prob. 2PCh. 19 - Assessing the Effect of Active-Site...Ch. 19 - Understanding the Mechanism of the -Ketoglutarate...Ch. 19 - Understanding the Action of Fluoroacetate on the...Ch. 19 - Prob. 6PCh. 19 - Prob. 7PCh. 19 - Prob. 8PCh. 19 - Prob. 9PCh. 19 - Prob. 10P
Ch. 19 - Prob. 11PCh. 19 - Prob. 12PCh. 19 - Prob. 13PCh. 19 - Prob. 14PCh. 19 - Prob. 15PCh. 19 - Prob. 16PCh. 19 - Understanding the Oxidation of Glucose and Its...Ch. 19 - Prob. 18PCh. 19 - Prob. 19PCh. 19 - Prob. 20PCh. 19 - Complete oxidation of a 16-carbon fatty acid can...Ch. 19 - Study Figure 19.18 and decide which of the...Ch. 19 - Prob. 23P
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Identify the Krebs cycle enzyme that consumes a 3-carbon substrate molecule, producing a 2- carbon product molecule (attached to acetyl-CoA), along with NADH, and one molecule of CO2. succinyl CoA synthetase a-ketoglutarate dehydrogenase pyruvate dehydrogenase isocitrate dehydrogenase malate dehydrogenasearrow_forwardElevated levels of acetyl-CoA will act as an effector for which of the following enzymes? more than one can be correct Pyruvate carboxylase. Pyruvate kinase Pyruvate dehydrogenase. Citrate synthase a-Ketoglutarate dehydrogenase.arrow_forwardElevated levels of acetyl-CoA will act as an effector for which of the following enzymes? Pyruvate carboxylase. Pyruvate kinase Pyruvate dehydrogenase. Citrate synthase a-Ketoglutarate dehydrogenase.arrow_forward
- In the pyruvae dehydrogensae complex, acetyl-coa is released by the dihydrolipoyl transacetylase activity. What is the purpose of the following enzymatic activity.arrow_forwardComplete the following description of the mechanism of the pyruvate dehydrogenase complex by using words provided. Not all words will be used. Each word will be used only one time. Three enzymes of the pyruvate dehydrogenase complex work together to catalyze the production of Acetyl CoA from Pyruvate. First, a 2-carbon unit composed of Carbons # ____ and ____ of Pyruvate are added to the co-enzyme ______ and whereas Carbon # ______ leaves as CO. The C-2 unit together with the co-enzyme is called ______ .The C-2 unit is then transferred to the 2nd co-enzyme ____, which is initially in it ___ state. The enzyme that catalyzes this step is ______.From here, the C-2 unit is transferred to form a _____ linkage with CoA-SH to generate_____arrow_forwardWhich of the following is TRUE? O Both AMP and ADP are negative regulators of glycogenolysis. ATP shifts the curve of glycogen phosphorylase to the left. O Citrate binds covalently to acetyl CoA carboxylase. Phosphofructokinase-1 is an allosterically regulated enzyme in glycolysis. The carnitine shuttle is positively regulated by Malonyl CoA.arrow_forward
- The conversion of pyruvate to Acetyl-CoA involves an oxidative decarboxylation. Correct the path of the electrons through this mechanism: Pyruvate -> NAD -> lipoamide -> FAD -> TPParrow_forwardIf we label the two carbons composing the acetyl group of acetyl-CoA with 14C, a radioactive isotope of carbon, and this labeled acetyl-CoA enters the TCA cycle, then which CO2 released by one turn of the TCA cycle will be labeled? 1) Both. 2) Only the CO2 released by the oxidation of alpha-ketoglutarate. 3) Only the CO2 released by the oxidation of isocitrate. 4) Neither.arrow_forwardConsider the following fatty acyl-CoA: CH3CH2CH2CH2CH2CH2CH2CH2CH=CHCH2CH=CHCH2 CH2CH2CH2CO- S-COA (18 carbon atoms; 2 double bonds). Which of the following is the correct output of Acetyl-CoA, ATP, NADH, FADH2 following the beta-oxidation of the fatty acid? A 9; 9; 9; 7 B 9; 0; 8; 6 9; 0; 8; 7 D 9; 0; 6; 8 E) 8; 0; 8; 8arrow_forward
- Indicate whether each of the following statements is true or false. If false, correct the statement or provide a brief explanation for why it is false. Malonyl-CoA inhibits carnitine acyltransferase II , thus slowing transport of fatty acyl-CoA into mitochondrial matrix.arrow_forwardIf Vitamin B1 is deficient, which of the following intermediates is/are likely to accumulate inmitochondria? Pyruvate a-ketoglutarate Both A and B Neither A nor B Malonyl-CoA synthesized by the action of acetyl-CoA carboxylase II is primarily used: To synthesize fatty acids To inhibit fatty acid oxidation Both A and B Neither A nor Barrow_forwardHow similar of an effect would a mutation in pyruvate dehydrogenase have, compared to a mutation in pyruvate carboxylase that blocks its ability to be regulated by acetyl-CoA?arrow_forward
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