BIOLOGY
12th Edition
ISBN: 9781260169614
Author: Raven
Publisher: RENT MCG
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Textbook Question
Chapter 18.1, Problem 2LO
Describe the pros and cons of restriction mapping, chromosome mapping, and mapping by STS.
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List three clinical indications for chromosome and/or genome analysis and why the process might be important for each indication.
a. How do scientists apply the concept of linkage disequilibrium to identify disease alleles?
b. Which specific phrase is used when such markers are identified by restriction endonucleases and a particular set of DNA fragments is generated?
STR markers:
are point mutations detectable by DNA sequencing
are variations in the number of repeats of very short DNA motifs (2-10 nucleotides)
□have high polymorphism
are mutations leading to proteins or blood groups that can be differentiated by antigenic testing from a blood sample
☐have low polymorphism
no correct answer
are changes of a few nucleotides leading to the absence or presence of a site recognized by a restriction enzyme
are variations in the number of repeats of medium-sized DNA motifs (10-100 nucleotides)
can be located in coding sequences
are located exclusively on autosomes
Chapter 18 Solutions
BIOLOGY
Ch. 18.1 - Prob. 1LOCh. 18.1 - Describe the pros and cons of restriction mapping,...Ch. 18.1 - Prob. 3LOCh. 18.2 - Discriminate between dideoxy terminator sequencing...Ch. 18.2 - Prob. 2LOCh. 18.3 - Describe the findings of the Human Genome Project.Ch. 18.3 - Prob. 2LOCh. 18.3 - Prob. 3LOCh. 18.4 - Prob. 1LOCh. 18.4 - Prob. 2LO
Ch. 18.4 - Prob. 3LOCh. 18.5 - Prob. 1LOCh. 18.5 - Prob. 2LOCh. 18.5 - Prob. 3LOCh. 18.6 - Prob. 1LOCh. 18 - Prob. 1DACh. 18 - If the human genome contains approximately 3...Ch. 18 - Prob. 1IQCh. 18 - Prob. 2IQCh. 18 - Prob. 3IQCh. 18 - Prob. 4IQCh. 18 - Prob. 5IQCh. 18 - Prob. 6IQCh. 18 - A genetic map provides a. the sequence of the DNA...Ch. 18 - Prob. 2UCh. 18 - Approximately how many genes are there in the...Ch. 18 - An open reading frame (ORF) is distinguished by...Ch. 18 - What is a BLAST search? a. A mechanism for...Ch. 18 - Prob. 6UCh. 18 - Prob. 7UCh. 18 - Prob. 8UCh. 18 - Prob. 1ACh. 18 - Prob. 2ACh. 18 - Prob. 3ACh. 18 - Prob. 4ACh. 18 - What information can be obtained from a DNA...Ch. 18 - Prob. 6ACh. 18 - Prob. 7ACh. 18 - You are in the early stages of a genome-sequencing...Ch. 18 - Genomic research can be used to determine if an...
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- Describe and give examples of direct reversal of DNA damage.arrow_forwardDescribe the multiple strand displacement method and how this technique is usedarrow_forwardDraw a diagram depicting the 4 steps of base excision repair, and give a short description of what is going on in each step..arrow_forward
- Explain how DNA microarrays are used in molecular profiling ofcancerous tumors.arrow_forwardWhy is DNA microarray an important tool and explain How is DNA microarray used in detecting cancer?arrow_forwardCre-Lox system is used for site-specific modification of DNA for genetic engineering applications. The reporter gene construct shown below is used to test the Cre-Lox system. Cells are transfected with the construct shown below and the activity of the constructs is determined by visualizing the cells with a fluorescence microscope. Match the following conditions with the expected cell observations. Hint: Make sure you note the position of the Start and Stop. The GFP and RFP genes shown do not have start codons. Cre/Lox Reporter Gene ATG LoxP CMV-Pro A. No Expression GFP Stop B. GFP Only LoxP Absence of Cre Cells treated with drug that induces expression of Cre RFP C. RFP Only A. Image A B. Image B C. Image C D Image D express ? D. RFP and GFParrow_forward
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