Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Question
Chapter 18, Problem 8QP
Summary Introduction
To determine: Whether the obtained results by the given pedigree analysis are satisfactory or not.
Introduction: The variations which occur in the genetic material of the organism from a source or randomly are called mutations. Single gene mutations can cause behavioral disorders in an organism.
Summary Introduction
To determine: The chances that tone deafness and perfect pitch can be alleles of a gene for musical ability.
Introduction: The variations which occur in the genetic material of the organisms from a source or randomly are called mutations. Single gene mutations can cause behavioral disorders in an organism.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
In a cross in Drosophila, a female heterozygous for the autosomallylinked genes a, b, c, d, and e (abcde/ + + + + +) was testcrossedwith a male homozygous for all recessive alleles (abcde/abcde).Even though the distance between each of the loci was at least3 map units, only four phenotypes were recovered, yielding thefollowing data:
Phenotype No. of Flies+ + + + + 440a b c d e 460+ + + + e 48a b c d + 52 Total = 1000
Why are many expected crossover phenotypes missing? Can anyof these loci be mapped from the data given here? If so, determinemap distances.
Concordance studies of twins for a neurodegenerative disorder show MZ=
46% and DZ= 15%. Further studies have shown a possible link to a gene
on chromosome 9, however, there are some individuals in the study who
have the allele but do not develop the disorder (group 1), and there are
other individuals who do not have the allele yet develop the disorder
(group 2). Amita's older sister and maternal uncle have this disorder.
Currently, Amita & her 2 younger brothers do not show symptoms. Amita's
paternal grandfather was rumored to have this disorder.
1. Draw the pedigree for Amita's family and determine the mode of
inheritance if any.
2. Explain how the 2 groups in the study could be possible?
3. What would you tell Amita about the heritability of this disorder?
Dominant negative
Incomplete dominance
Epistasis
Recessive lethal allele
III
|||
E
A condition where one gene has the ability to
override the expression of another gene no matter
what the relationship is between the other gene's
alleles.
A condition when a new mutation is able to suppress
or revert an earlier mutation allowing wildtype
function to reappear.
A condition where a recessive allele influences the
shape of a protein dimer product in the
heterozygous condition so that it neither resembles
the homozygous dominant nor the homozygous
recessive conditions leading to a LOF in the
heterozygous state and the recessive state.
A condition where two recessive alleles will be fatal
to an offspring although it will not affect a
Chapter 18 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 18.2 - What role would twin and adoption studies play in...Ch. 18.2 - Prob. 2EGCh. 18 - Why do you think it has been so difficult to...Ch. 18 - If a test were available that could tell you...Ch. 18 - Prob. 1QPCh. 18 - Prob. 2QPCh. 18 - Prob. 3QPCh. 18 - List the steps involved in transmitting a nerve...Ch. 18 - Why do neurotransmitters have to be removed from...Ch. 18 - Prob. 6QP
Ch. 18 - Perfect pitch is the ability to identify a note...Ch. 18 - Prob. 8QPCh. 18 - Name three genes whose mutations lead to an...Ch. 18 - Prob. 10QPCh. 18 - Prob. 11QPCh. 18 - Animal Models: The Search for Behavior Genes You...Ch. 18 - Prob. 13QPCh. 18 - A pedigree analysis was performed on the family of...Ch. 18 - Prob. 15QPCh. 18 - A region on chromosome 6 has been linked to...Ch. 18 - Genetics and Social Behavior Of the following...Ch. 18 - Prob. 18QPCh. 18 - Prob. 19QP
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Many genetic disorders exhibit locus heterogeneity. Define andgive two examples of locus heterogeneity. How does locus heterogeneityconfound a pedigree analysis?arrow_forwardThe pedigree below shows that inheritance of a disease that is caused by a late onset, dominant, autosomal mutation that is rare, but only 50% penetrant. The gene that is mutated in the disease is linked at a distance of 10 cm to a microsatellite marker that has alleles numbered 1, 2, and 3. The marker alleles detected in each individual are indicated below. What is the probability that individual A will develop the disease? Explain using an illustration of this occurs.arrow_forwardHere is a family pedigree for an imprinting disorder caused by a loss of function mutation in a single imprinted gene. After generation I only related individuals are shown. You can assume that the parents not included in the pedigree did not carry the mutation. %3D II IV V Male O Female Affected Carrier a) Does the mutation involve a gene that is normally expressed from the maternal or from the paternal allele? Briefly explain your logic. b) Identify two ways in which the pattern of inheritance shown in the pedigree is different from X-linked inheritance I. Parthenogenesis has been documented in most vertebrate Classes (e.g. birds, fish) but never in mammals. Genomic imprinting provides one explanation for this observation. Why?arrow_forward
- The following genotypes of two independently assorting autosomal genes determine coat color in rats:A-B- (gray); A-bb (yellow); aaB-(black); aabb (cream)A third gene pair on a separate autosome determines whetherany color will be produced. The CC and Cc genotypes allow coloraccording to the expression of the A and B alleles. However,the cc genotype results in albino rats regardless of the A and Balleles present. Determine the F1 phenotypic ratio of the followingcrosses: (a)AAbbCC * aaBBcc; (b) AaBBcc * AABbcc;(c) AaBbCc * AaBbcc.arrow_forwardTake the example of B-thalassemia, an autosomal recessive genetic disease that particularly affects people from around the Mediterranean. This disease is associated with an anomaly of hemoglobin, a protein essential for the transport of oxygen, which is composed of four chains: two alpha (a) and two beta (B). In case of B-thalassemia, the ẞ chains are produced in insufficient or no quantity in an individual homozygous recessive resulting in insufficient production of overall hemoglobin leading to anemia and other physiological challenges. The gene that controls the synthesis of the ẞ chains is located on chromosome 11. Here is part of the coding portion of this gene (which controls a total of 146 amino acids and of which you only see the portion 36 to 41) and one of the targeted mutations: 1. Give the sequence of amino acids from the template and mutated strands. 2. What type of point mutation is it? 3. Using the principles of the theory of evolution, explain briefly and generally why…arrow_forwardGoatee A Bearding in goats is inherited as an autosomal trait determined by two alleles, B1 and B2. Interestingly, the bearded trait is recessive in females, while it is dominant in males. In both sexes, homozygotes for the B1 allele are beardless. Which of the following is true? (more than one correct answer possible) Males with the genotype B1B1 are beardless Females with the genotype B1B2 are beardrd Males with the genotype B1B2 are bearded Females with the genotype B1B1 are bearded Females with the genotype B2B2 are beardless. Males with the genotype B2B2 are beardedarrow_forward
- A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known concordance statistics, would his MZ twin be at high risk for the disease? Would the twins risk decrease if he were raised in an environment different from that of his schizophrenic brother?arrow_forwardHemophilia and color blindness are both recessive conditions caused by genes on the X chromosome. To calculate the recombination frequency between the two genes, you draw a large number of pedigrees that include grandfathers with both hemophilia and color blindness, their daughters (who presumably have one chromosome with two normal alleles and one chromosome with two mutant alleles), and the daughters sons. Analyzing all the pedigrees together shows that 25 grandsons have both color blindness and hemophilia, 24 have neither of the traits, 1 has color blindness only, and 1 has hemophilia only. How many centimorgans (map units) separate the hemophilia locus from the locus for color blindness?arrow_forwardFamilial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals): a. Circle the individual(s) in which the mutation most likely occurred. b. Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer. c. Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?arrow_forward
- Two unlinked loci effect mouse hair color. AA or Aa mice are agouti. Mice with genotype aa are albino because all pigment production and deposition of pigment in hair is blocked. At the second locus, the B allele (black agouti coat) is dominant to the b allele (brown agouti coat). A mouse with an unknown genotype is mated with an albino mouse of genotype bbaa. Half of the offspring are albino, one quarter are black agouti, and one quarter are brown agouti. What is the genotype of the unknown parent?arrow_forwardThe complete absence of one or more teeth (tooth agenesis) is a common trait in humans—indeed, more than 20% of humans lack one or more of their third molars. However, more severe tooth agenesis, defined as the absence of six or more teeth, is less common and is frequently an inherited condition. L. Lammi and colleagues examined tooth agenesis in the Finnish family shown in the pedigree below. Q.If III-2 and III-7 married and had a child, what is the probability that their child would have tooth agenesis?arrow_forwardBlack body (b) and purple eye (pr) are recessive autosomal mutations in Drosophila. Bridges are crossed b/b females with pr/pr males and in the F2 observed 684 wild type, 371 black-bodied, and 300 purple-eyed flies. Do these results indicate that the b and pr genes are closely linked? Explain. (Remember that there is no crossing-over in male Drosophila)..arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Animal Communication | Ecology & Environment | Biology | FuseSchool; Author: FuseSchool - Global Education;https://www.youtube.com/watch?v=LsMbn3b1Bis;License: Standard Youtube License