Human Heredity: Principles and Issues (MindTap Course List)
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 18, Problem 15QP
Summary Introduction

To determine: The genetic nature of a bipolar disorder.

Introduction: A bipolar disorder (manic-depressive disorder) is a type of mental illness which affects a number of human beings per year. This condition occurs during the adolescence or in the second and third decades of life.

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The Xb locus on Alouatta genus, the howler monkey X chromosome has 2 alleles, b+ and b. The b+ allele causes the presence of the Xb surface protein on their granulocyte cells, while the recessive allele b which does not allow the antigen to appear. The Xb locus is at 15 centimorgans, from the GRG locus. The GRG locus produces a normal enzyme activity. Individual howler monkeys with one form of an eye condition have the grg/grg genotype, with the males grg/Y presenting the condition. A male howler monkey with the eye condition caused by this enzyme mutation and no Xb antigen has a normal female howler monkey daughter with Xb antigen. This howler monkey female daughter is expecting a little howler monkey from the mating from a male howler monkey from a different tree. A) Determine the genotype of the howler monkey daughter, from the problem. B) Determine the types and percentages of each gametes in oogenesis produced of the howler monkey daughter female, based on the map distance given.…
Match each example of mutation to the correct effect on function. Hypomorphic mutation Hypermorphic mutation Antimorphic mutation Neomorphic A deletion results in the loss of part of a protein and the protein retains some of its normal activity. A mutant allele makes a protein with increased cataytic activity. A mutant form of a transcription factor binds new DNA sequences to activate different genes. A mutant from of a receptor protein interferes with the function of the wild-type receptor through heterodimerization.
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