Concept explainers
Interpretation:
Effect of hemoglobin when substitution of valine for glutamic acid in primary structure of hemoglobin has to be identified.
Concept introduction:
Many amino acids are linked together through amide bonds to form a biologically large molecule known to be proteins.
Amino
Primary structure of protein is a sequence in which the amino acids linked by peptide bond in a protein.
Sickle-cell anemia is a hereditary disease caused by genetic difference that replaces one amino acid (glutamate) with another in each of the two polypeptide chains of the hemoglobin.
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Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
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